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NCT01342510 · ClinicalTrials.gov registry record · Phase 4
Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol
A Phase 4 study, sponsored by University of Wisconsin, Madison.
- Completed
- Registry status
- Phase 4
- Development phase
- 200
- Enrollment target
NCT01342510 is a Phase 4 study that has completed, run by University of Wisconsin, Madison. The registered enrollment target is 200 participants.
The verdict
NCT01342510, a Phase 4 study, has completed, sponsored by University of Wisconsin, Madison.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 200 participants
- Enrollment target
Study Summary
Since the introduction of propofol into routine anesthesia practice, the phenomena of pain on injection has plagued anesthesia providers. Propofol, an unstable phenol, triggers the release of bradykinin on injection. This release causes a painful burning sensation in the patient at the site of injection. Anesthesia providers have attempted a large number of remedies to prevent this pain on injection. Previously explored ideas include injecting propofol into larger veins, warming of the hand with hot packs, and intravenous pretreatment with numerous other medications. Currently, pretreatment with lidocaine is commonly administered to prevent propofol injection pain. No studies to date have looked at the combination of lidocaine and magnesium in a single syringe for the pretreatment of pain on injection caused by propofol. In addition, the administration protocols that have been studied thus far do not mirror clinical practice at the University of Wisconsin. The investigators propose studying the use of magnesium and lidocaine in a single syringe for pretreatment of propofol related pain on injection.
Interventions
- DRUG Lidocaine
- DRUG Magnesium Sulfate
- DRUG Control
- DRUG Lidocaine/Magnesium
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2011-04 |
| Est. Completion | 2012-04 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01342510
The ClinicalTrials.gov registry entry for NCT01342510 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Wisconsin, Madison, which has 1,039 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Lidocaine is the first listed.
NCT01342510 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01342510 about?
NCT01342510 is a clinical study titled "Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol". Since the introduction of propofol into routine anesthesia practice, the phenomena of pain on injection has plagued anesthesia providers. Propofol, an unstable phenol, triggers the release of bradykinin on injection. This release causes a painful burning sensation in the patient at the site of injec...
What is the current status of trial NCT01342510?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 200 participants. The study started on 2011-04. Estimated completion is 2012-04.
What interventions are being tested in trial NCT01342510?
The interventions under investigation include: Lidocaine (DRUG), Magnesium Sulfate (DRUG), Control (DRUG), Lidocaine/Magnesium (DRUG).
Who is sponsoring clinical trial NCT01342510?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
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