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NCT01324245 · ClinicalTrials.gov registry record · NA
Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet
A NA study, sponsored by Georgetown University.
- Completed
- Registry status
- NA
- Development phase
- 45
- Enrollment target
NCT01324245: Completed NA study, sponsored by Georgetown University.
NCT01324245 is a NA study that has completed, run by Georgetown University. The registered enrollment target is 45 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01324245, a NA study, has completed, sponsored by Georgetown University.
- COMPLETED
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
Study Summary
The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension occurs when this balance is altered or abnormal. We hypothesized that this balance is influenced by salt intake: therefore dietary salt affects the natriuretic response to the renal dopaminergic agonist Fenoldopam, and the Angiotensin Converting Enzyme inhibitor, Enalapril. In this trial we study normal salt balance mechanisms in salt resistant adults with normal blood pressure.
Primary Outcome
All subjects received placebo/enalapril in a randomized counterbalanced fashion in both phases. Phase 1 was on low salt, while Phase 2 was on high salt. All subjects received a 3 hour fenoldopam infusion, during which time urinary sodium excretion was measured as the primary outcome bvariable.
Interventions
- DRUG Fenoldopam
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2002-11 |
| Est. Completion | 2006-05 |
| Phase | NA |
What the finished NCT01324245 record still lists
NCT01324245 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which Fenoldopam is the first listed.
NCT01324245 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01324245 about?
NCT01324245 is a clinical study titled "Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet". The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension occurs when this balance is altered or abn...
What is the current status of trial NCT01324245?
This trial is currently completed. It is a NA study. The enrollment target is 45 participants. The study started on 2002-11. Estimated completion is 2006-05.
What interventions are being tested in trial NCT01324245?
The interventions under investigation include: Fenoldopam (DRUG).
Who is sponsoring clinical trial NCT01324245?
This trial is sponsored by Georgetown University, which has 227 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01324245's enrollment target sits among peer trials
45 1411th of 2000 higher than 578 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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