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NCT01322672 · ClinicalTrials.gov registry record
Peri-Anesthetic Imaging of Cognitive Dysfunction
A clinical trial, sponsored by Vanderbilt University.
- Completed
- Registry status
- 6
- Enrollment target
NCT01322672: Completed study, sponsored by Vanderbilt University.
NCT01322672 is a clinical trial that has completed, run by Vanderbilt University. The registered enrollment target is 6 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01322672 has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- 6 participants
- Enrollment target
Study Summary
Recent data suggests that anesthetics can have prolonged effects on gene expression, protein synthesis and processing as well as cellular function in ways that the investigators are only beginning to understand, especially in the very young and the elderly. Within moments to days of emerging from anesthesia - cardiac or non-cardiac - some patients experience mild to very severe disorientation and changes in memory and thinking ability without apparent cause. For the vast majority of patients, this Post-Operative Cognitive Dysfunction (POCD), generally subsides, but for some with "diminished cognitive reserve" - especially the elderly, those with less education or prior CNS events such as stroke or early dementia - changes in memory and executive function may persist. If prolonged for more than three months, POCD has been linked to an increased risk of death. In 1-2% of elderly patients, the problem may ultimately continue for more than a year, leading to a loss of ability to care for themselves and early demise. Though this may seem like a small percentage, seniors will comprise up to 40% of the 50-75 million surgical procedures performed annually over the next 20-30 years. This amounts to 70,000 - 200,000 elder affected, and for them and their families, the cost of POCD in longer-term care, lost wages, and extended suffering will remain very high.
Primary Outcome
Anesthetics can have prolonged effects on gene expression, protein synthesis and processing as well as cellular function, especially in the very young and the elderly. After anesthesia, some patients experience mild to very severe disorientation and even delirium without apparent cause. In the elderly, this Post-Operative Cognitive Dysfunction (POCD) - including changes in memory and executive function may persist and has been linked to an increased risk of death. Over the next 20-30 years, 40%
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2011-03 |
| Est. Completion | 2015-08-27 |
What the finished NCT01322672 record still lists
NCT01322672 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 6 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01322672 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01322672 about?
NCT01322672 is a clinical study titled "Peri-Anesthetic Imaging of Cognitive Dysfunction". Recent data suggests that anesthetics can have prolonged effects on gene expression, protein synthesis and processing as well as cellular function in ways that the investigators are only beginning to understand, especially in the very young and the elderly. Within moments to days of emerging from an...
What is the current status of trial NCT01322672?
This trial is currently completed. The enrollment target is 6 participants. The study started on 2011-03. Estimated completion is 2015-08-27.
Who is sponsoring clinical trial NCT01322672?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
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