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NCT01288014 · ClinicalTrials.gov registry record
Cytokine Production and Immunity to Varicella Zoster Virus (VZV) in Elderly Recipients of Zoster Vaccine
A clinical trial, sponsored by Columbia University.
- Completed
- Registry status
- 26
- Enrollment target
NCT01288014: Completed study, sponsored by Columbia University.
NCT01288014 is a clinical trial that has completed, run by Columbia University. The registered enrollment target is 26 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01288014 has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- 26 participants
- Enrollment target
Study Summary
After immunization, particularly in older persons, some people are protected from disease by a vaccine and others are not. The investigators believe that this variable response may be due to overproduction of molecules that suppress development of immunity (antibodies and cell mediated immunity). Normally, these molecules are produced to make sure that immunity is regulated in just the right way for the body as a whole, and to prevent autoimmune disease. However, with aging, the immune system may have difficulty in proper immune regulation. Over production of immunosuppressive molecules after vaccination may interfere with the effects of a vaccine. For example when elderly individuals are immunized against zoster with a licensed vaccine, Zostavax, the vaccine is effective in only about 50 to 60%. The investigators will compare blood levels of antibodies, cellular immunity, and immunosuppressive molecules in recipients of Zostavax to see if there is a correlation between development low immunity and high levels of immunosuppressive molecules.
Primary Outcome
Measure antibodies, cellular immunity, and cytokines in blood before and after immunization. Determine if there is any relationship between development of strong immunity and development of cytokine levels.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2011-01 |
| Est. Completion | 2012-03 |
What the finished NCT01288014 record still lists
NCT01288014 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 26 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01288014 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01288014 about?
NCT01288014 is a clinical study titled "Cytokine Production and Immunity to Varicella Zoster Virus (VZV) in Elderly Recipients of Zoster Vaccine". After immunization, particularly in older persons, some people are protected from disease by a vaccine and others are not. The investigators believe that this variable response may be due to overproduction of molecules that suppress development of immunity (antibodies and cell mediated immunity). No...
What is the current status of trial NCT01288014?
This trial is currently completed. The enrollment target is 26 participants. The study started on 2011-01. Estimated completion is 2012-03.
Who is sponsoring clinical trial NCT01288014?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
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