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NCT01288014 · ClinicalTrials.gov registry record
Cytokine Production and Immunity to Varicella Zoster Virus (VZV) in Elderly Recipients of Zoster Vaccine
A clinical trial, sponsored by Columbia University.
- Completed
- Registry status
- 26
- Enrollment target
NCT01288014 is a clinical trial that has completed, run by Columbia University. The registered enrollment target is 26 participants.
The verdict
NCT01288014 has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- 26 participants
- Enrollment target
Study Summary
After immunization, particularly in older persons, some people are protected from disease by a vaccine and others are not. The investigators believe that this variable response may be due to overproduction of molecules that suppress development of immunity (antibodies and cell mediated immunity). Normally, these molecules are produced to make sure that immunity is regulated in just the right way for the body as a whole, and to prevent autoimmune disease. However, with aging, the immune system may have difficulty in proper immune regulation. Over production of immunosuppressive molecules after vaccination may interfere with the effects of a vaccine. For example when elderly individuals are immunized against zoster with a licensed vaccine, Zostavax, the vaccine is effective in only about 50 to 60%. The investigators will compare blood levels of antibodies, cellular immunity, and immunosuppressive molecules in recipients of Zostavax to see if there is a correlation between development low immunity and high levels of immunosuppressive molecules.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2011-01 |
| Est. Completion | 2012-03 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01288014
The ClinicalTrials.gov registry entry for NCT01288014 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 26 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Columbia University, which has 958 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT01288014 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01288014 about?
NCT01288014 is a clinical study titled "Cytokine Production and Immunity to Varicella Zoster Virus (VZV) in Elderly Recipients of Zoster Vaccine". After immunization, particularly in older persons, some people are protected from disease by a vaccine and others are not. The investigators believe that this variable response may be due to overproduction of molecules that suppress development of immunity (antibodies and cell mediated immunity). No...
What is the current status of trial NCT01288014?
This trial is currently completed. The enrollment target is 26 participants. The study started on 2011-01. Estimated completion is 2012-03.
Who is sponsoring clinical trial NCT01288014?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
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