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NCT01272349 · ClinicalTrials.gov registry record · Phase 1
Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI
A Phase 1 study, sponsored by Emory University.
- Completed
- Registry status
- Phase 1
- Development phase
- 19
- Enrollment target
NCT01272349 is a Phase 1 study that has completed, run by Emory University. The registered enrollment target is 19 participants.
The verdict
NCT01272349, a Phase 1 study, has completed, sponsored by Emory University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 19 participants
- Enrollment target
Study Summary
The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury. This idea stems from animal studies on respiration, in which investigators have shown that mild intermittent hypoxia improves breathing in spinally injured rats. These studies have shown that intermittent hypoxia induces spinal plasticity, strengthening neural connections and motor neuron function within the spinal cord. Exposure to mild intermittent hypoxia triggers a cascade of events, including increased production of key proteins and increased sensitivity of spinal cord circuitry necessary for improved breathing. The ultimate goal of this research is to assess the potential of mild intermittent hypoxia as a therapeutic approach to stimulate recovery of limb function in human patients.
Interventions
- OTHER Room air
- OTHER Acute intermittent hypoxia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2010-12 |
| Est. Completion | 2013-11 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01272349
The ClinicalTrials.gov registry entry for NCT01272349 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 19 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Emory University, which has 1,208 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Room air is the first listed.
NCT01272349 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01272349 about?
NCT01272349 is a clinical study titled "Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI". The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury. This idea stems from animal studies on respiration, in which investigators have shown that mild intermittent hypox...
What is the current status of trial NCT01272349?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 19 participants. The study started on 2010-12. Estimated completion is 2013-11.
What interventions are being tested in trial NCT01272349?
The interventions under investigation include: Room air (OTHER), Acute intermittent hypoxia (OTHER).
Who is sponsoring clinical trial NCT01272349?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
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