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NCT01237210 · ClinicalTrials.gov registry record
7T MRS in Parkinson's Disease
A clinical trial, sponsored by University of Minnesota.
- Completed
- Registry status
- 78
- Enrollment target
NCT01237210: Completed study, sponsored by University of Minnesota.
NCT01237210 is a clinical trial that has completed, run by University of Minnesota. The registered enrollment target is 78 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01237210 has completed, sponsored by University of Minnesota.
- COMPLETED
- Registry status
- 78 participants
- Enrollment target
Study Summary
This study is looking for healthy controls and patients with Parkinson's (PD) to perform an MR scan. 1. The neurochemical profile of the SN of patients with PD as measured by high field MRS will differ from that of healthy controls, in that glutathione will be lower due to oxidative stress, lactate will be higher due to mitochondrial dysfunction, the gliosis markers myo-inositol and glutamine will be higher due to inflammation (glial activation) and N-acetylaspartate and glutamate will be lower due to neuronal loss/damage. 2. There will be a relationship between neurochemical changes and disease severity.
Primary Outcome
We will utilize optimized magnetic resonance spectroscopy (MRS) methodology to address theories of pathogenesis of Parkinson's disease (PD) by quantifying glutathione (GSH), lactate, glutamine and myo-inositol levels of the unilateral substantia nigra (SN) of healthy volunteers and patients with PD.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 78 participants |
| Start Date | 2010-02 |
| Est. Completion | 2019-02 |
What the finished NCT01237210 record still lists
NCT01237210 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 78 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01237210 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01237210 about?
NCT01237210 is a clinical study titled "7T MRS in Parkinson's Disease". This study is looking for healthy controls and patients with Parkinson's (PD) to perform an MR scan. 1. The neurochemical profile of the SN of patients with PD as measured by high field MRS will differ from that of healthy controls, in that glutathione will be lower due to oxidative stress, lactate...
What is the current status of trial NCT01237210?
This trial is currently completed. The enrollment target is 78 participants. The study started on 2010-02. Estimated completion is 2019-02.
Who is sponsoring clinical trial NCT01237210?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
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