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NCT01194323 · ClinicalTrials.gov registry record
Biology in Patients With Reflux Esophagitis
A clinical trial, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- 75
- Enrollment target
NCT01194323: Completed study, sponsored by Vanderbilt University Medical Center.
NCT01194323 is a clinical trial that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 75 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01194323 has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- 75 participants
- Enrollment target
Study Summary
GERD is a common condition in the western world. In most cases, the diagnostic is established by good response to empiric proton pump inhibitor (PPI) therapy. When the patient symptoms are refractory to therapy, multiple invasive tests are available. The results of those tests (EGD, manometry, Ph monitoring and impedance) are clues that the physician use together to establish the diagnostic. No test however can be use alone because of their poor specificity and sensitivity. Recently, microscopy has been used to detect dilated intercellular space in between distal esophageal cells tissue; unfortunately this marker again failed to diagnose GERD. In search of more sensitive and specific markers of GERD, we propose to assess if acid exposure affects: 1) gene and proteins expression in the esophageal/post-cricoid area tissue; and 2) local impedance of the mucosa. The secondary aim of this proposal is to determine if correlation exists between the two approaches.
Primary Outcome
We are assessing if acid exposure affects gene and protein expression in the esophageal/post-cricoid area tissue
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2010-11 |
| Est. Completion | 2012-12 |
What the finished NCT01194323 record still lists
NCT01194323 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 75 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01194323 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01194323 about?
NCT01194323 is a clinical study titled "Biology in Patients With Reflux Esophagitis". GERD is a common condition in the western world. In most cases, the diagnostic is established by good response to empiric proton pump inhibitor (PPI) therapy. When the patient symptoms are refractory to therapy, multiple invasive tests are available. The results of those tests (EGD, manometry, Ph mo...
What is the current status of trial NCT01194323?
This trial is currently completed. The enrollment target is 75 participants. The study started on 2010-11. Estimated completion is 2012-12.
Who is sponsoring clinical trial NCT01194323?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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