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NCT01190085 · ClinicalTrials.gov registry record · NA
Effects of Ghrelin on Alcohol Cue Reactivity and Craving
A NA study, sponsored by Brown University.
- Completed
- Registry status
- NA
- Development phase
- 45
- Enrollment target
NCT01190085 is a NA study that has completed, run by Brown University. The registered enrollment target is 45 participants.
The verdict
NCT01190085, a NA study, has completed, sponsored by Brown University.
- COMPLETED
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
Study Summary
Only a few medications are approved for the treatment of alcohol dependence and there exists a substantial need for discovering ways to provide more effective treatments. Accordingly, identifying new potential neuropharmacological targets in the treatment of alcohol dependence represents a high priority in public health. Ghrelin is a 28-amino acid peptide acting as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). Ghrelin was first isolated from the stomach, but a central hypothalamic production of ghrelin has also been demonstrated. Ghrelin plays a key role in the regulation of appetite. Consistent with the common neurobiological substrates for control of food and alcohol consumption, preclinical investigations suggest that ghrelin plays a role in the neurobiology of alcohol dependence, thus representing a new potential neuropharmacology target. In keeping with the preclinical studies, human investigations showed that alcohol consumption affects blood ghrelin levels and that blood ghrelin levels significantly and positively correlate with craving measurements in alcohol-dependent individuals. The effects of exogenous ghrelin injected intravenous (i.v.) in alcohol-dependent individuals, however, have never been investigated. The current project proposes a randomized double-blind placebo-controlled 3-group between-subject laboratory study aimed at investigating the effects of exogenous ghrelin i.v. on non-treatment seeking alcohol-dependent subjects in terms of urges to drink, attention to cues and related psychophysiological measures. This project has the goals to: i) conduct an alcohol laboratory study testing the role of ghrelin i.v., therefore demonstrating the feasibility of such a study and the safety of ghrelin i.v. when administered to alcohol-dependent individuals; and ii) explore the effects of ghrelin i.v. on alcohol craving assessed under controlled conditions, such as a cue-reactivity (CR) experiment. This study will address wh
Interventions
- DRUG Saline solution
- DRUG Ghrelin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2011-04 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01190085
The ClinicalTrials.gov registry entry for NCT01190085 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Brown University, which has 231 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Saline solution is the first listed.
NCT01190085 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01190085 about?
NCT01190085 is a clinical study titled "Effects of Ghrelin on Alcohol Cue Reactivity and Craving". Only a few medications are approved for the treatment of alcohol dependence and there exists a substantial need for discovering ways to provide more effective treatments. Accordingly, identifying new potential neuropharmacological targets in the treatment of alcohol dependence represents a high prio...
What is the current status of trial NCT01190085?
This trial is currently completed. It is a NA study. The enrollment target is 45 participants. The study started on 2011-04.
What interventions are being tested in trial NCT01190085?
The interventions under investigation include: Saline solution (DRUG), Ghrelin (DRUG).
Who is sponsoring clinical trial NCT01190085?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
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