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NCT01173705 · ClinicalTrials.gov registry record
Factors Involved in Obesity-related Inflammation and Insulin Resistance
A clinical trial, sponsored by Vanderbilt University.
- Terminated
- Registry status
- 62
- Enrollment target
NCT01173705: Clinical Trial study, sponsored by Vanderbilt University.
NCT01173705 is a clinical trial that was terminated before completion, run by Vanderbilt University. The registered enrollment target is 62 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01173705 was terminated before completion, sponsored by Vanderbilt University.
- TERMINATED
- Registry status
- 62 participants
- Enrollment target
Study Summary
In this project, we propose to recruit lean and obese subjects with different ethnic background (African Americans and Caucasians) to study the alterations of lipid and carbohydrate metabolism and determine whether these disturbances are linked to genetic, inflammatory, oxidative stress, and/or nutritional factors. Because systemic inflammation and insulin resistance are frequent features of obesity, we postulate that an unbalanced diet with high saturated- and low omega 3-fatty acids is linked to obesity-related inflammation and insulin resistance. We propose to investigate fatty acid metabolism and determine the links between fatty acid composition and oxidative stress in tissues of lean and obese subjects. We propose the following aims: Specific Aim 1: Evaluate nutrient intake in lean and obese subjects using the standard NHANES Food Questionnaire. Specific Aim 2: Evaluate the fatty acid composition, including omega-3, in adipose tissue depots, blood monocytes and skeletal muscle, and examine the relationship between omega-3 content and inflammatory and oxidative stress markers. Specific Aim 3: Compare the effects of omega-3 and saturated FA supplementation on inflammatory and oxidative stress markers in vitro in adipose tissue explants, preadipocytes and monocyte culture.
Primary Outcome
We will evaluate fatty acid composition in adipose tissues depots, blood monocytes, and skeletal muscle to examine the relationship between omega-e content and inflammatory and oxidative stress markers.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2011-06 |
| Est. Completion | 2014-01 |
Why NCT01173705 stopped before completion
NCT01173705 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 62 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01173705 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01173705 about?
NCT01173705 is a clinical study titled "Factors Involved in Obesity-related Inflammation and Insulin Resistance". In this project, we propose to recruit lean and obese subjects with different ethnic background (African Americans and Caucasians) to study the alterations of lipid and carbohydrate metabolism and determine whether these disturbances are linked to genetic, inflammatory, oxidative stress, and/or nutr...
What is the current status of trial NCT01173705?
This trial is currently terminated. The enrollment target is 62 participants. The study started on 2011-06. Estimated completion is 2014-01.
Who is sponsoring clinical trial NCT01173705?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
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