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NCT01169831 · ClinicalTrials.gov registry record · NA
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
A NA study, sponsored by Baltimore VA Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT01169831: Completed NA study, sponsored by Baltimore VA Medical Center.
NCT01169831 is a NA study that has completed, run by Baltimore VA Medical Center. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01169831, a NA study, has completed, sponsored by Baltimore VA Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.
Interventions
- OTHER Exercise Training
- OTHER Exercise Cessation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2011-07 |
| Est. Completion | 2024-07-31 |
| Phase | NA |
What the finished NCT01169831 record still lists
NCT01169831 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Exercise Training is the first listed.
NCT01169831 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01169831 about?
NCT01169831 is a clinical study titled "Regulation of Endothelial Progenitor Cells by Short-Term Exercise". Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and functi...
What is the current status of trial NCT01169831?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2011-07. Estimated completion is 2024-07-31.
What interventions are being tested in trial NCT01169831?
The interventions under investigation include: Exercise Training (OTHER), Exercise Cessation (OTHER).
Who is sponsoring clinical trial NCT01169831?
This trial is sponsored by Baltimore VA Medical Center, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01169831's enrollment target sits among peer trials
60 1164th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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