Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01169831 · ClinicalTrials.gov registry record · NA
Regulation of Endothelial Progenitor Cells by Short-Term Exercise
A NA study, sponsored by Baltimore VA Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT01169831 is a NA study that has completed, run by Baltimore VA Medical Center. The registered enrollment target is 60 participants.
The verdict
NCT01169831, a NA study, has completed, sponsored by Baltimore VA Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.
Interventions
- OTHER Exercise Training
- OTHER Exercise Cessation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2011-07 |
| Est. Completion | 2024-07-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01169831
The ClinicalTrials.gov registry entry for NCT01169831 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Baltimore VA Medical Center, which has 12 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Exercise Training is the first listed.
NCT01169831 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01169831 about?
NCT01169831 is a clinical study titled "Regulation of Endothelial Progenitor Cells by Short-Term Exercise". Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and functi...
What is the current status of trial NCT01169831?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2011-07. Estimated completion is 2024-07-31.
What interventions are being tested in trial NCT01169831?
The interventions under investigation include: Exercise Training (OTHER), Exercise Cessation (OTHER).
Who is sponsoring clinical trial NCT01169831?
This trial is sponsored by Baltimore VA Medical Center, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.