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NCT01165190 · ClinicalTrials.gov registry record
Effect of Pioglitazone on Mitochondrial Function in Muscle and Adipose Tissue in Humans
A clinical trial, sponsored by Arizona State University.
- Completed
- Registry status
- 20
- Enrollment target
NCT01165190: Completed study, sponsored by Arizona State University.
NCT01165190 is a clinical trial that has completed, run by Arizona State University. The registered enrollment target is 20 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01165190 has completed, sponsored by Arizona State University.
- COMPLETED
- Registry status
- 20 participants
- Enrollment target
Study Summary
Mitochondrial dysfunction in skeletal muscle results in decreased muscle fatty acid oxidation, leading to conversion of fatty acids into triglycerides and its accumulation inside the muscle tissue. Moreover, in adipose tissue mitochondrial dysfunction results in decreased fatty acid oxidation and triglyceride synthesis, leading to increased circulating fatty acid concentrations, which in turn also leads to lipid accumulation inside muscle tissue. Lipid accumulation inside muscle tissue interferes with the insulin signaling pathway and causes insulin resistance. Mitochondrial dysfunction in both tissues has therefore been proposed to play an important role in insulin resistance in humans. Pioglitazone, a thiazolidinedione, is an FDA approved medication for the treatment of type 2 diabetes. It improves muscle insulin sensitivity at least in part by lowering intramuscular lipid concentrations but the mechanism by which this occurs is unclear. In the present study, we shall therefore test the hypothesis that pioglitazone improves mitochondrial function in muscle and adipose tissue in humans who are insulin resistant.
Interventions
- OTHER pioglitazone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2008-05 |
| Est. Completion | 2010-05 |
What the finished NCT01165190 record still lists
NCT01165190 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 20 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which pioglitazone is the first listed.
NCT01165190 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01165190 about?
NCT01165190 is a clinical study titled "Effect of Pioglitazone on Mitochondrial Function in Muscle and Adipose Tissue in Humans". Mitochondrial dysfunction in skeletal muscle results in decreased muscle fatty acid oxidation, leading to conversion of fatty acids into triglycerides and its accumulation inside the muscle tissue. Moreover, in adipose tissue mitochondrial dysfunction results in decreased fatty acid oxidation and tr...
What is the current status of trial NCT01165190?
This trial is currently completed. The enrollment target is 20 participants. The study started on 2008-05. Estimated completion is 2010-05.
What interventions are being tested in trial NCT01165190?
The interventions under investigation include: pioglitazone (OTHER).
Who is sponsoring clinical trial NCT01165190?
This trial is sponsored by Arizona State University, which has 187 total clinical trials registered on ClinicalTrials.gov.
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