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NCT01158508 · ClinicalTrials.gov registry record · Phase 1
Remote Ischemic Preconditioning in Subarachnoid Hemorrhage
A Phase 1 study of Subarachnoid Hemorrhage and Intracranial Aneurysm, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT01158508 is a Phase 1 study of Subarachnoid Hemorrhage and Intracranial Aneurysm that has completed, run by University of California, Los Angeles. The registered enrollment target is 20 participants, below the 3,587-participant average among 21 other Subarachnoid Hemorrhage trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01158508, a Phase 1 study of Subarachnoid Hemorrhage and Intracranial Aneurysm, has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
Rupture of brain aneurysms is a common cause of death and disability, accounting for as many as 10% of stroke cases in the United States. While much of the resulting injury to the nervous system is caused by the initial bleeding from the aneurysm, many of these patients develop cerebral vasospasm, pathological constriction of the blood vessels supplying the brain, several days following hemorrhage. As many as a third of patients can suffer a resulting neurological deficit and stroke, presumably caused by the decreased blood flow to the brain (ischemia). This delayed brain injury accounts for a significant percentage of poor outcomes following aneurysm rupture. Studies have shown that remote ischemia to many organs can precondition other tissues (including the brain) to be more tolerant to decreases in blood flow. This "remote ischemic preconditioning" has the promise of protecting the brain from ischemic injury. Whereas in other forms of stroke the onset of ischemia cannot be predicted in the general population, following aneurysm rupture the investigators know which patients are likely to develop vasospasm and when. Therefore, ischemic preconditioning following aneurysm rupture may help prevent some of the ischemic injury caused by vasospasm. Remote ischemic preconditioning by transient limb ischemia (produced by inflation of a blood pressure cuff on the arm or leg) has been shown to minimize injury to other organs, most notably the heart. Remote ischemic preconditioning of the brain following aneurysm rupture has not yet been investigated.
Conditions Studied
Interventions
- PROCEDURE Remote ischemic preconditioning
Study Locations (1)
California
- UCLA Ronald Reagan Medical Center - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2010-04 |
| Est. Completion | 2014-07 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01158508
The ClinicalTrials.gov registry entry for NCT01158508 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 3,587-participant average among 21 other Subarachnoid Hemorrhage trials with a reported enrollment target (99% lower). The listed sponsor is University of California, Los Angeles, which has 897 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Subarachnoid Hemorrhage appearing as the primary indexed condition, and to 1 intervention - of which Remote ischemic preconditioning is the first listed.
NCT01158508 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT01158508 about?
NCT01158508 is a clinical study titled "Remote Ischemic Preconditioning in Subarachnoid Hemorrhage". Rupture of brain aneurysms is a common cause of death and disability, accounting for as many as 10% of stroke cases in the United States. While much of the resulting injury to the nervous system is caused by the initial bleeding from the aneurysm, many of these patients develop cerebral vasospasm, p...
What is the current status of trial NCT01158508?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2010-04. Estimated completion is 2014-07.
What conditions does trial NCT01158508 study?
This clinical trial studies the following conditions: Subarachnoid Hemorrhage, Intracranial Aneurysm, Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm.
What interventions are being tested in trial NCT01158508?
The interventions under investigation include: Remote ischemic preconditioning (PROCEDURE).
Who is sponsoring clinical trial NCT01158508?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01158508 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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