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NCT01110863 · ClinicalTrials.gov registry record
Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects
A clinical trial, sponsored by Northwell Health.
- Completed
- Registry status
- 90
- Enrollment target
NCT01110863: Completed study, sponsored by Northwell Health.
NCT01110863 is a clinical trial that has completed, run by Northwell Health. The registered enrollment target is 90 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01110863 has completed, sponsored by Northwell Health.
- COMPLETED
- Registry status
- 90 participants
- Enrollment target
Study Summary
By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric analysis we can measure how quickly new B-CLL cells are generated in the bone marrow and how quickly they leave the blood, a measure of cell turnover. This will help us to better understand the unique characteristics of this disease process.
Primary Outcome
B-CLL is a dx of accumulation rather than proliferation. Evidence for various forms of clonal evolution suggests that B-CLL clones may be more dynamic than previously assumed. A non-radioactive, stable isotopic labeling method to measure B-CLL cell kinetics in vivo. Subjects drank an aliquot of 2H2O daily for 84 days, and 2H incorporation into the deoxyribose moiety of DNA of their newly divided B-CLL cells, measured by gc/ms, during the labeling period. Birth rates were calculated from the kine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2005-12 |
| Est. Completion | 2016-02-12 |
What the finished NCT01110863 record still lists
NCT01110863 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 90 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01110863 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01110863 about?
NCT01110863 is a clinical study titled "Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects". By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric an...
What is the current status of trial NCT01110863?
This trial is currently completed. The enrollment target is 90 participants. The study started on 2005-12. Estimated completion is 2016-02-12.
Who is sponsoring clinical trial NCT01110863?
This trial is sponsored by Northwell Health, which has 370 total clinical trials registered on ClinicalTrials.gov.
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