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NCT01097954 · ClinicalTrials.gov registry record
A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma
A clinical trial, sponsored by Winthrop University Hospital.
- Completed
- Registry status
- 22
- Enrollment target
NCT01097954: Completed study, sponsored by Winthrop University Hospital.
NCT01097954 is a clinical trial that has completed, run by Winthrop University Hospital. The registered enrollment target is 22 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01097954 has completed, sponsored by Winthrop University Hospital.
- COMPLETED
- Registry status
- 22 participants
- Enrollment target
Study Summary
Exercise induced bronchospasm (EIB), also known as exercise induced asthma (EIA) is a transient obstruction to airflow triggered by exertion. It is now a well known identity, center of discussion in recent years, particularly in the athletes' world. It is more common in asthmatic individuals (regardless of severity of disease), but it is also seen in otherwise healthy subjects, leading to the general consensus that the pathophysiology is different than asthma. The concentration of exhaled nitric oxide (FeNO) in various airway \& respiratory disorders, particularly asthma, has been deeply studied. Its use for noninvasive monitoring of asthma control (reflecting airway eosinophilic inflammation) is being closely examined and put into clinical practice. FeNO is significantly elevated in asthma. Elevated FeNO levels have also been noted in patients hospitalized with a COPD exacerbation, acidosis, rhinitis, bronchiectasis, active pulmonary sarcoidosis, active fibrosing alveolitis, and acute lung allograft rejection. Decreased FeNO levels have been seen in patients with primary ciliary dyskinesia, cystic fibrosis, PiZZ phenotype-related alpha-1 antitrypsin deficiency, and pulmonary hypertension Two studies have addressed the variations on FeNO after EIB and they had contradictory results. Scollo et al. found no change in FeNO in either healthy or asthmatic children after a 6-min of vigorous exertion in an exercise laboratory when they studied 24 asthmatic and 18 control children. Terada et al. reported, for 39 subjects, a decrease in FeNO in subjects with EIB and an increase in healthy controls. It is well accepted that the pathophysiology of exercise induced bronchospasm it is not similar to that of asthma. Certainly the inflammation in the airway does not appear to be eosinophilic. Understanding the disease mechanism is a key factor to adequately manage it. This will be a prospective study measuring online exhaled nitric oxide involving children 8 to 21 years old.
Primary Outcome
The exhaled Nitric Oxide (FeNO) will be measured before the exercise test and at 5, 10 and 15 min after completion of the exercise to detect variations in the value
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2010-04 |
| Est. Completion | 2013-06 |
What the finished NCT01097954 record still lists
NCT01097954 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 22 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01097954 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01097954 about?
NCT01097954 is a clinical study titled "A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma". Exercise induced bronchospasm (EIB), also known as exercise induced asthma (EIA) is a transient obstruction to airflow triggered by exertion. It is now a well known identity, center of discussion in recent years, particularly in the athletes' world. It is more common in asthmatic individuals (regar...
What is the current status of trial NCT01097954?
This trial is currently completed. The enrollment target is 22 participants. The study started on 2010-04. Estimated completion is 2013-06.
Who is sponsoring clinical trial NCT01097954?
This trial is sponsored by Winthrop University Hospital, which has 32 total clinical trials registered on ClinicalTrials.gov.
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