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NCT01076660 · ClinicalTrials.gov registry record
Left Ventricular Structural Predictors of Sudden Cardiac Death
A clinical trial of Ischemic Cardiomyopathy and Nonischemic Cardiomyopathy, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- 400
- Enrollment target
- 2
- Study locations
NCT01076660 is a study of Ischemic Cardiomyopathy and Nonischemic Cardiomyopathy that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 400 participants, above the 339-participant average among 10 other Ischemic Cardiomyopathy trials with a reported enrollment target (18% higher). The trial reports 2 study locations across 2 states.
The verdict
NCT01076660, a study of Ischemic Cardiomyopathy and Nonischemic Cardiomyopathy, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- 400 participants
- Enrollment target
- 2
- Study locations
Study Summary
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic burden. Moreover, in using current practice guidelines of reduced heart function, specifically left ventricular ejection fraction (LVEF)≤35%, as the main determining factor for patient selection, only a minority of patients actually benefit from ICD therapy (\<25% in 5 years). There is an essential need for more robust diagnostic approaches to SCD risk stratification. This project examines the hypothesis that structural abnormalities of the heart itself, above and beyond global LV dysfunction, are important predictors of SCD risk since they indicate the presence of the abnormal tissue substrate required for the abnormal electrical circuits and heart rhythms that actually lead to SCD. Information about the heart's structure will be obtained from cardiac magnetic resonance imaging and used in combination with a number of other clinical risk factors to see if certain characteristics can better predict patients at risk for SCD.
Conditions Studied
Study Locations (2)
Delaware
- Christiana Care Health Services - Newark
Maryland
- Johns Hopkins Medical Institutions - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2003-10 |
| Est. Completion | 2030-06 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01076660
The ClinicalTrials.gov registry entry for NCT01076660 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 400 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 339-participant average among 10 other Ischemic Cardiomyopathy trials with a reported enrollment target (18% higher). The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Ischemic Cardiomyopathy appearing as the primary indexed condition, and to 0 interventions.
NCT01076660 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Delaware, Maryland.
Frequently Asked Questions
What is clinical trial NCT01076660 about?
NCT01076660 is a clinical study titled "Left Ventricular Structural Predictors of Sudden Cardiac Death". Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function. However, the critical survival benefit afforded by the devices is accompanied by sh...
What is the current status of trial NCT01076660?
This trial is currently recruiting. The enrollment target is 400 participants. The study started on 2003-10. Estimated completion is 2030-06.
What conditions does trial NCT01076660 study?
This clinical trial studies the following conditions: Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy.
Who is sponsoring clinical trial NCT01076660?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01076660 being conducted?
This trial has 2 study locations across Delaware, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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