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NCT01054404 · ClinicalTrials.gov registry record · NA
Furosemide vs Placebo for Brain Relaxation
A NA study, sponsored by Northwestern University.
- Terminated
- Registry status
- NA
- Development phase
- 23
- Enrollment target
NCT01054404 is a NA study that was terminated before completion, run by Northwestern University. The registered enrollment target is 23 participants.
The verdict
NCT01054404, a NA study, was terminated before completion, sponsored by Northwestern University.
- TERMINATED
- Registry status
- NA
- Development phase
- 23 participants
- Enrollment target
Study Summary
Increased brain bulk may be problematic during brain surgery for tumors because it may limit surgical exposure and access to the surgical site. Mannitol, an osmotic diuretic, is commonly given to alleviate brain bulk, and sometimes furosemide in a small dose is added if mannitol alone is insufficient. It is unclear if adding this furosemide truly helps to diminish brain bulk, and it is possible that furosemide may cause too much diuresis, leading to dehydration and its side effects (e.g., low blood pressure). Our purpose is to investigate what the effects of furosemide are in the setting of brain surgery for tumors, specifically with regards to decreasing brain bulk and/or causing dehydration. Study Hypothesis: The addition of furosemide to mannitol will result in improved brain relaxation in human subjects undergoing craniotomy for brain tumor resection than that seen with mannitol alone. However, the combination of mannitol and furosemide will also lead to more significant intravascular volume depletion than that seen with mannitol alone.
Interventions
- DRUG Placebo
- DRUG Furosemide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2010-02 |
| Est. Completion | 2012-03 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01054404
The ClinicalTrials.gov registry entry for NCT01054404 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 23 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT01054404 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01054404 about?
NCT01054404 is a clinical study titled "Furosemide vs Placebo for Brain Relaxation". Increased brain bulk may be problematic during brain surgery for tumors because it may limit surgical exposure and access to the surgical site. Mannitol, an osmotic diuretic, is commonly given to alleviate brain bulk, and sometimes furosemide in a small dose is added if mannitol alone is insufficien...
What is the current status of trial NCT01054404?
This trial is currently terminated. It is a NA study. The enrollment target is 23 participants. The study started on 2010-02. Estimated completion is 2012-03.
What interventions are being tested in trial NCT01054404?
The interventions under investigation include: Placebo (DRUG), Furosemide (DRUG).
Who is sponsoring clinical trial NCT01054404?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
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