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NCT01049191 · ClinicalTrials.gov registry record
Bone Microarchitecture in Women With and Without Fracture
A clinical trial, sponsored by University of Wisconsin, Madison.
- Completed
- Registry status
- 78
- Enrollment target
NCT01049191: Completed study, sponsored by University of Wisconsin, Madison.
NCT01049191 is a clinical trial that has completed, run by University of Wisconsin, Madison. The registered enrollment target is 78 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01049191 has completed, sponsored by University of Wisconsin, Madison.
- COMPLETED
- Registry status
- 78 participants
- Enrollment target
Study Summary
Osteoporosis is a common disorder of compromised bone strength causing 40-50% of women and \~25% of men to sustain fragility fractures during their lifetime. The reduction of bone strength in osteoporotic people results from loss of bone density and deterioration of bone quality. Bone quality is a complex amalgamation including macro- and micro-architecture, mineralization, turnover and damage accumulation. Currently, medications to reduce fracture risk are prescribed primarily on the basis of bone mineral density (BMD) measurement. Unfortunately, currently available BMD measurement technologies do not detect the aforementioned properties of bone quality; as such, less than half of individuals who sustain osteoporotic fractures are classified as "osteoporotic" by currently available diagnostic tools. Clearly, measures to enhance identification of those at high fracture risk are needed. High-resolution magnetic resonance imaging (HR-MRI) technology, such as that provided by MicroMRI, Inc., has outstanding potential to be such a tool. Therefore, our long-term goal is to evaluate and optimize the use of HR-MRI in fracture risk prediction; this pilot work is an essential step in attaining this goal. This research will investigate 72 postmenopausal women with normal or osteopenic BMD by dual-energy x-ray absorptiometry (DXA), 36 with prior low-trauma fractures will be compared with 36 age-, race- and BMD matched women without fracture. We hypothesize that 1.) Women with fractures will have evidence of microarchitectural deterioration on HR-MRI and 2.) Newly developed, more rapid MRI sequences designed at the UW will provide similar trabecular microstructure information more rapidly than the currently used, albeit investigational, technology produced by MicroMRI, Inc. Our specific aims are to a) Evaluate differences in MicroMRI parameters of trabecular microstructure (bone volume fraction, trabecular thickness, surface/curve ratio and erosion index) between age-, race-
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 78 participants |
| Start Date | 2008-10 |
| Est. Completion | 2010-05 |
What the finished NCT01049191 record still lists
NCT01049191 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 78 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01049191 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01049191 about?
NCT01049191 is a clinical study titled "Bone Microarchitecture in Women With and Without Fracture". Osteoporosis is a common disorder of compromised bone strength causing 40-50% of women and \~25% of men to sustain fragility fractures during their lifetime. The reduction of bone strength in osteoporotic people results from loss of bone density and deterioration of bone quality. Bone quality is a c...
What is the current status of trial NCT01049191?
This trial is currently completed. The enrollment target is 78 participants. The study started on 2008-10. Estimated completion is 2010-05.
Who is sponsoring clinical trial NCT01049191?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
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