Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01040338 · ClinicalTrials.gov registry record
Effects of Nicotine on Brain Opioid Receptors
A clinical trial, sponsored by University of Pennsylvania.
- Terminated
- Registry status
- 15
- Enrollment target
NCT01040338: Clinical Trial study, sponsored by University of Pennsylvania.
NCT01040338 is a clinical trial that was terminated before completion, run by University of Pennsylvania. The registered enrollment target is 15 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01040338 was terminated before completion, sponsored by University of Pennsylvania.
- TERMINATED
- Registry status
- 15 participants
- Enrollment target
Study Summary
A substantial body of evidence implicates the endogenous opioid system, and the mu opioid receptor (MOR) in particular, in the reinforcing effects of drugs of abuse, including nicotine. A single nucleotide polymorphism (SNP) in the mu opioid receptor gene (OPRM1 Asp40) is associated with the ability to quit smoking, as well as nicotine reward and withdrawal symptoms. However, the precise mechanism through which this SNP influences nicotine dependence remains unresolved. This positron emission tomography (PET) study will examine whether this OPRM1 SNP alters MOR binding in response to nicotine in human smokers. Specifically, we will use \[11 C\]carfentanil PET imaging to assess the effects of intravenous (IV) nicotine versus saline (within-subject) on MOR binding potential in 24 chronic smokers genotyped prospectively and stratified by OPRM1 genotype.
Interventions
- DRUG Nicotine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2010-02 |
| Est. Completion | 2011-03 |
Why NCT01040338 stopped before completion
NCT01040338 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 15 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Nicotine is the first listed.
NCT01040338 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01040338 about?
NCT01040338 is a clinical study titled "Effects of Nicotine on Brain Opioid Receptors". A substantial body of evidence implicates the endogenous opioid system, and the mu opioid receptor (MOR) in particular, in the reinforcing effects of drugs of abuse, including nicotine. A single nucleotide polymorphism (SNP) in the mu opioid receptor gene (OPRM1 Asp40) is associated with the ability...
What is the current status of trial NCT01040338?
This trial is currently terminated. The enrollment target is 15 participants. The study started on 2010-02. Estimated completion is 2011-03.
What interventions are being tested in trial NCT01040338?
The interventions under investigation include: Nicotine (DRUG).
Who is sponsoring clinical trial NCT01040338?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01889381 · 15 participants · Phase 2
Human Craniomaxillofacial Allotransplantation
- NCT02530073 · 15 participants · NA
Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) for CDH
- NCT02535936 · 15 participants · NA
Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
- NCT02918474 · 15 participants · NA
Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia