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NCT01037660 · ClinicalTrials.gov registry record · Early Phase 1
Effects of Lipemia and Metformin on Endothelial Function
A Early Phase 1 study, sponsored by Boston University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 139
- Enrollment target
NCT01037660: Completed Early Phase 1 study, sponsored by Boston University.
NCT01037660 is a Early Phase 1 study that has completed, run by Boston University. The registered enrollment target is 139 participants, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (162% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01037660, a Early Phase 1 study, has completed, sponsored by Boston University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 139 participants
- Enrollment target
Study Summary
Eating a diet high in fat contributes to the development of atherosclerosis (hardening of the arteries). Acute fat consumption increases levels of fat in the blood and temporarily reduces the ability of blood vessel to dilate (open up to carry additional blood). A similar response is observed during infusion of Intra-Lipid (a fat emulsion used for intravenous nutrition). The present study is designed to help us understand the effects of a fat load on blood vessel function. We will measure arterial dilation using non-invasive techniques before and at the end of a 5-hour infusion of Intra-Lipid in healthy subjects. Subjects will then take the approved drug metformin for two weeks and return for repeat studies of endothelial function with Intra-Lipid infusion. We expect that metformin will help preserve the normal function of blood vessels during a fat load. This study will help us understand how fat affects blood vessels and therefore will advance our knowledge of the development of atherosclerosis and potentially lead to improved methods to prevent and treat heart disease.
Interventions
- DRUG Metformin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 139 participants |
| Start Date | 2005-09 |
| Est. Completion | 2016-12-01 |
| Phase | Early Phase 1 |
What the finished NCT01037660 record still lists
NCT01037660 is an interventional study that assigns participants to a tested intervention. The registered 139 participants enrollment target is mid-sized for trials with a published cap, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (162% higher).
The record links to 0 conditions, and to 1 intervention - of which Metformin is the first listed.
NCT01037660 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01037660 about?
NCT01037660 is a clinical study titled "Effects of Lipemia and Metformin on Endothelial Function". Eating a diet high in fat contributes to the development of atherosclerosis (hardening of the arteries). Acute fat consumption increases levels of fat in the blood and temporarily reduces the ability of blood vessel to dilate (open up to carry additional blood). A similar response is observed during...
What is the current status of trial NCT01037660?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 139 participants. The study started on 2005-09. Estimated completion is 2016-12-01.
What interventions are being tested in trial NCT01037660?
The interventions under investigation include: Metformin (DRUG).
Who is sponsoring clinical trial NCT01037660?
This trial is sponsored by Boston University, which has 185 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01037660's enrollment target sits among peer trials
139 122nd of 2000 higher than 1,879 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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