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NCT01037465 · ClinicalTrials.gov registry record · NA
ROS Signaling in Endothelial Function
A NA study, sponsored by Boston University.
- Completed
- Registry status
- NA
- Development phase
- 72
- Enrollment target
NCT01037465 is a NA study that has completed, run by Boston University. The registered enrollment target is 72 participants.
The verdict
NCT01037465, a NA study, has completed, sponsored by Boston University.
- COMPLETED
- Registry status
- NA
- Development phase
- 72 participants
- Enrollment target
Study Summary
The vascular endothelium (inner lining of cells in blood vessels) normally prevents vasospasm and thrombosis by producing nitric oxide and other regulatory substances. In patients with atherosclerosis, endothelial function is impaired. Excess production of reactive oxygen species (free radicals) contribute to endothelial dysfunction in atherosclerosis, and some prior studies have shown a beneficial effect of antioxidant treatment on endothelial function in patients with coronary artery disease. On the other hand, reactive oxygen species may be required for normal endothelial function and antioxidant supplements failed to show a benefit in large clinical trials. The effect of antioxidant treatment on endothelial function in healthy subjects is unknown. The present study will test the hypothesis that scavenging reactive species might reduce endothelium-dependent vasodilation in healthy subjects. The study is a randomized, double-blind, placebo-controlled crossover study. Participants will receive 2.4 grams of oral NAC or similar-appearing placebo during the first visit, and then will cross over to the alternative treatment (NAC or placebo) for the second and final visit. We will examine endothelial function before and after treatment on each visit.
Interventions
- DRUG Placebo
- DRUG N-acetylcysteine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2008-09 |
| Est. Completion | 2016-03-26 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01037465
The ClinicalTrials.gov registry entry for NCT01037465 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Boston University, which has 185 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT01037465 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01037465 about?
NCT01037465 is a clinical study titled "ROS Signaling in Endothelial Function". The vascular endothelium (inner lining of cells in blood vessels) normally prevents vasospasm and thrombosis by producing nitric oxide and other regulatory substances. In patients with atherosclerosis, endothelial function is impaired. Excess production of reactive oxygen species (free radicals) con...
What is the current status of trial NCT01037465?
This trial is currently completed. It is a NA study. The enrollment target is 72 participants. The study started on 2008-09. Estimated completion is 2016-03-26.
What interventions are being tested in trial NCT01037465?
The interventions under investigation include: Placebo (DRUG), N-acetylcysteine (DRUG).
Who is sponsoring clinical trial NCT01037465?
This trial is sponsored by Boston University, which has 185 total clinical trials registered on ClinicalTrials.gov.
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