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NCT01035060 · ClinicalTrials.gov registry record
Blood Flow, Muscle Regeneration and Sarcopenia
A clinical trial, sponsored by University of Florida.
- Completed
- Registry status
- 68
- Enrollment target
NCT01035060: Completed study, sponsored by University of Florida.
NCT01035060 is a clinical trial that has completed, run by University of Florida. The registered enrollment target is 68 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01035060 has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- 68 participants
- Enrollment target
Study Summary
Due to the rapid aging of the population, sarcopenia is among the greatest challenges facing the health care system over the next quarter century. This age-related loss of skeletal muscle mass and strength directly contributes to the incidence of functional disability, thereby reducing independence and quality of life for the elderly. Despite increasing efforts to combat sarcopenia, its etiology remains incompletely described. Subsequently, limited progress has been made in developing comprehensive preventative and therapeutic strategies to combat the problem. A decreased ability to regenerate skeletal muscle fibers through the donation of skeletal muscle stem cells (satellite cells) is thought to contribute to sarcopenia. However, the upstream physiological mediators that regulate this impairment are poorly delineated. Reduced muscle blood flow in advanced age appears to be a significant factor in reducing skeletal muscle regenerative capacity, but few data exist to confirm this hypothesis. Thus to test this hypothesis we aim to conduct a translational pilot trial which examines regeneration in both young and old adults. Furthermore, we aim to determine if muscle blood flow and satellite cell number are associated with muscle function. The central hypothesis of this proposal is that age-related declines in skeletal muscle angiogenesis and perfusion are significant causal factors in age-related losses of skeletal muscle mass. The specific aims and hypotheses of the project are as follows:
Primary Outcome
Change in the number of myonuclear cells identified as Pax7+ following contraction-induced skeletal muscle injury. Cells identified as Pax7+ by immunohistochemistry of skeletal muscle biopsy samples. Data adjusted for gender, physical activity level, and baseline satellite cell number.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2010-06 |
| Est. Completion | 2011-12 |
What the finished NCT01035060 record still lists
NCT01035060 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 68 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01035060 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01035060 about?
NCT01035060 is a clinical study titled "Blood Flow, Muscle Regeneration and Sarcopenia". Due to the rapid aging of the population, sarcopenia is among the greatest challenges facing the health care system over the next quarter century. This age-related loss of skeletal muscle mass and strength directly contributes to the incidence of functional disability, thereby reducing independence ...
What is the current status of trial NCT01035060?
This trial is currently completed. The enrollment target is 68 participants. The study started on 2010-06. Estimated completion is 2011-12.
Who is sponsoring clinical trial NCT01035060?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
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