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NCT01027559 · ClinicalTrials.gov registry record · NA
fMRI Study of Treatment Changes in Major Depression
A NA study, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- NA
- Development phase
- 97
- Enrollment target
NCT01027559: Completed NA study, sponsored by Washington University School of Medicine.
NCT01027559 is a NA study that has completed, run by Washington University School of Medicine. The registered enrollment target is 97 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01027559, a NA study, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 97 participants
- Enrollment target
Study Summary
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional antidepressants do, and in comparison to healthy controls with no history of depression, to find out more about the causes of depression including differences in the extent of problems caused by depression. We hypothesize that CBT will have the same healing effect on the brain as antidepressants; that differences in brain activations created by the various tasks and genetic differences will help us understand differences in the type and severity of symptoms among the depressed subjects.
Primary Outcome
MRI imaging was completed on 50 participants (26 depressed who were randomized to the CBT group and 24 controls) for this analysis, including fMRI scans to evaluate regional brain activation in depression during an emotional distractor task. Image data from their baseline visit was processed and analyzed to show differences in blood oxygen-level dependent (BOLD) activations between depressed participants in the CBT group and control participants in a priori regions (amygdala and dorsolateral pre
Interventions
- BEHAVIORAL Cognitive Behavioral Therapy
- DRUG Sertraline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 97 participants |
| Start Date | 2009-02 |
| Est. Completion | 2014-01 |
| Phase | NA |
What the finished NCT01027559 record still lists
NCT01027559 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 97 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 2 interventions - of which Cognitive Behavioral Therapy is the first listed.
NCT01027559 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01027559 about?
NCT01027559 is a clinical study titled "fMRI Study of Treatment Changes in Major Depression". The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional antidepressants do, and in comparison to healthy controls with no history of depression, to find out more about the causes o...
What is the current status of trial NCT01027559?
This trial is currently completed. It is a NA study. The enrollment target is 97 participants. The study started on 2009-02. Estimated completion is 2014-01.
What interventions are being tested in trial NCT01027559?
The interventions under investigation include: Cognitive Behavioral Therapy (BEHAVIORAL), Sertraline (DRUG).
Who is sponsoring clinical trial NCT01027559?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01027559's enrollment target sits among peer trials
97 923rd of 2000 higher than 1,076 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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