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NCT01011465 · ClinicalTrials.gov registry record · NA
The Biology of Resilience
A NA study, sponsored by Harvard School of Public Health (HSPH).
- Completed
- Registry status
- NA
- Development phase
- 270
- Enrollment target
NCT01011465: Completed NA study, sponsored by Harvard School of Public Health (HSPH).
NCT01011465 is a NA study that has completed, run by Harvard School of Public Health (HSPH). The registered enrollment target is 270 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (81% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01011465, a NA study, has completed, sponsored by Harvard School of Public Health (HSPH).
- COMPLETED
- Registry status
- NA
- Development phase
- 270 participants
- Enrollment target
Study Summary
Positive social relationships have consistently been associated with better health, although the neurobiological underpinnings of these observed effects remain largely unknown. The overall goal of the proposed work is to explore novel biological pathways that may explain how social relationships influence health. Recent theorizing suggests that the oxytocin system may underlie some of the observed beneficial effects. Four hypotheses will be examined: 1. Oxytocin ameliorates the deleterious neuroendocrine, cardiovascular, and subjective effects of stress. 2. Oxytocin and social support have similar and additive stress-buffering effects. 3. Effects of oxytocin are evident among younger and older adults. 4. Effects of oxytocin are stronger in women vs men.
Primary Outcome
Systolic blood pressure (SBP)is connected with reaction to exposure to stress. Systolic blood pressure is collected at baseline and after nasal spray administration/directly before stress tasks; it represents anticipatory stress reaction. This measure represents the difference between baseline and pre-task systolic blood pressure values. A greater difference score represents an increase from baseline in systolic blood pressure during the pre-task, and so a larger difference score represents high
Interventions
- DRUG Placebo
- DRUG intranasal oxytocin
- BEHAVIORAL Social support
- BEHAVIORAL No Social Support
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 270 participants |
| Start Date | 2009-02 |
| Est. Completion | 2012-04 |
| Phase | NA |
What the finished NCT01011465 record still lists
NCT01011465 is an interventional study that assigns participants to a tested intervention. The registered 270 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (81% lower).
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT01011465 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01011465 about?
NCT01011465 is a clinical study titled "The Biology of Resilience". Positive social relationships have consistently been associated with better health, although the neurobiological underpinnings of these observed effects remain largely unknown. The overall goal of the proposed work is to explore novel biological pathways that may explain how social relationships inf...
What is the current status of trial NCT01011465?
This trial is currently completed. It is a NA study. The enrollment target is 270 participants. The study started on 2009-02. Estimated completion is 2012-04.
What interventions are being tested in trial NCT01011465?
The interventions under investigation include: Placebo (DRUG), intranasal oxytocin (DRUG), Social support (BEHAVIORAL), No Social Support (BEHAVIORAL).
Who is sponsoring clinical trial NCT01011465?
This trial is sponsored by Harvard School of Public Health (HSPH), which has 40 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01011465's enrollment target sits among peer trials
270 387th of 2000 higher than 1,609 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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