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NCT01007994 · ClinicalTrials.gov registry record · Phase 2
Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients
A Phase 2 study of Hypertension Secondary to Kidney Transplant, sponsored by Northwell Health.
- Completed
- Registry status
- Phase 2
- Development phase
- 33
- Enrollment target
- 2
- Study locations
NCT01007994: Completed Phase 2 study of Hypertension Secondary to Kidney Transplant, sponsored by Northwell Health.
NCT01007994 is a Phase 2 study of Hypertension Secondary to Kidney Transplant that has completed, run by Northwell Health. The registered enrollment target is 33 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (75% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01007994, a Phase 2 study of Hypertension Secondary to Kidney Transplant, has completed, sponsored by Northwell Health.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 33 participants
- Enrollment target
- 2
- Study locations
Study Summary
The proposed study investigated the effect of chronotherapeutic alteration of anti-hypertensive medication on nocturnal hypertension and end-organ injury in pediatric renal transplant recipients who are non-dippers. Additionally, the investigators examined the association between response to intervention, serum adiponectin levels and adiponectin gene polymorphisms. The investigators hypothesized that (1) evening administration of anti-hypertensive medication will convert subjects from non-dipper to dipper status, improve mean nocturnal blood pressure (BP), and improve nocturnal BP load, (2) evening administration of anti-hypertensive medication will reduce albuminuria, left ventricular mass index (LVMI), rate of decline of glomerular filtration rate (eGFR) and will decrease pulse wave velocity (PWV).
Primary Outcome
Percentage of subjects in each of the treatment arms who are nondippers, defined as systolic or diastolic nocturnal dip \<10%
Conditions Studied
Interventions
- DRUG New Medication: Enalapril, Isradipine, Propranolol
Study Locations (2)
New York
- Cohen Children's Medical Center of NY - New Hyde Park
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 33 participants |
| Start Date | 2009-11 |
| Est. Completion | 2020-08 |
| Phase | Phase 2 |
What the finished NCT01007994 record still lists
NCT01007994 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 33 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (75% lower).
The record links to 1 condition, with Hypertension Secondary to Kidney Transplant appearing as the primary indexed condition, and to 1 intervention - of which New Medication: Enalapril, Isradipine, Propranolol is the first listed.
NCT01007994 reports a single indexed study location in New York, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01007994 about?
NCT01007994 is a clinical study titled "Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients". The proposed study investigated the effect of chronotherapeutic alteration of anti-hypertensive medication on nocturnal hypertension and end-organ injury in pediatric renal transplant recipients who are non-dippers. Additionally, the investigators examined the association between response to interve...
What is the current status of trial NCT01007994?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 33 participants. The study started on 2009-11. Estimated completion is 2020-08.
What conditions does trial NCT01007994 study?
This clinical trial studies the following conditions: Hypertension Secondary to Kidney Transplant.
What interventions are being tested in trial NCT01007994?
The interventions under investigation include: New Medication: Enalapril, Isradipine, Propranolol (DRUG).
Who is sponsoring clinical trial NCT01007994?
This trial is sponsored by Northwell Health, which has 370 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01007994 being conducted?
This trial has 2 study locations across New York, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01007994's enrollment target sits among peer trials
33 1553rd of 2000 higher than 438 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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