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NCT00991809 · ClinicalTrials.gov registry record · NA
Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 22
- Enrollment target
NCT00991809: Completed NA study, sponsored by Johns Hopkins University.
NCT00991809 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 22 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00991809, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 22 participants
- Enrollment target
Study Summary
The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end of the study.
Primary Outcome
The participant places their hand in a water bath kept at 4 degrees Celsius (cold pressor test). They then continue to hold the hand in the water bath until they can no longer tolerate the pain (pain tolerance) or until the end of the testing (truncated at 300 seconds for safety purposes). Reported as the mean (time to hand removal in seconds) at the 30 minute time point.
Interventions
- DRUG Diphenhydramine
- DRUG Alfentanil
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2009-02 |
| Est. Completion | 2010-05 |
| Phase | NA |
What the finished NCT00991809 record still lists
NCT00991809 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Diphenhydramine is the first listed.
NCT00991809 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00991809 about?
NCT00991809 is a clinical study titled "Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil". The purpose of this study was to follow a person's response to experimental pain after multiple consecutive exposures to alfentanil or diphenhydramine to see if the person can tolerate the pain more, less, or the same at the end of the study.
What is the current status of trial NCT00991809?
This trial is currently completed. It is a NA study. The enrollment target is 22 participants. The study started on 2009-02. Estimated completion is 2010-05.
What interventions are being tested in trial NCT00991809?
The interventions under investigation include: Diphenhydramine (DRUG), Alfentanil (DRUG).
Who is sponsoring clinical trial NCT00991809?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00991809's enrollment target sits among peer trials
22 1756th of 2000 higher than 239 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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