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NCT00970099 · ClinicalTrials.gov registry record · Phase 1
Mechanism of Insulin-Resistant in Lean Non-Diabetics
A Phase 1 study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 1
- Development phase
- 149
- Enrollment target
NCT00970099 is a Phase 1 study that has completed, run by University of California, San Francisco. The registered enrollment target is 149 participants.
The verdict
NCT00970099, a Phase 1 study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 149 participants
- Enrollment target
Study Summary
The study is designed to test the following primary hypothesis: * Aerobic exercise training will improve insulin sensitivity in insulin resistant subjects through changes in the major cellular signaling pathways and and/or their regulators. Accordingly, the proposed study is designed to accomplish the following specific aims: * Quantitate how exercise training improves insulin sensitivity and decreases cardiovascular risk factors in a general population of lean, nondiabetic, insulin resistant subjects. Effects on known cardiovascular risk factors including blood pressure and serum lipoproteins will be evaluated. Change in regional adiposity will also be measured * Determine the effects of a program of regular aerobic exercise on in the insulin receptor signaling pathway. Biopsies of vastus lateralis muscle from insulin resistant subjects will be obtained before and after a hyperinsulinemic glucose clamp. This procedure will take place in the untrained state and after exercise training. The investigators will measure changes in the insulin receptor and the activity of the major components of the intracellular insulin signaling pathway. The investigators will also look intracellular proteins that regulate this signaling pathway.
Interventions
- BEHAVIORAL exercise
- BEHAVIORAL Non exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 149 participants |
| Start Date | 2004-02 |
| Est. Completion | 2009-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00970099
The ClinicalTrials.gov registry entry for NCT00970099 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 149 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which exercise is the first listed.
NCT00970099 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00970099 about?
NCT00970099 is a clinical study titled "Mechanism of Insulin-Resistant in Lean Non-Diabetics". The study is designed to test the following primary hypothesis: * Aerobic exercise training will improve insulin sensitivity in insulin resistant subjects through changes in the major cellular signaling pathways and and/or their regulators. Accordingly, the proposed study is designed to accomplish...
What is the current status of trial NCT00970099?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 149 participants. The study started on 2004-02. Estimated completion is 2009-12.
What interventions are being tested in trial NCT00970099?
The interventions under investigation include: exercise (BEHAVIORAL), Non exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT00970099?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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