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NCT00952601 · ClinicalTrials.gov registry record · Phase 1
Pilot Study of the Modified Atkins Diet for Tourette Syndrome
A Phase 1 study, sponsored by Johns Hopkins University.
- Terminated
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT00952601: Clinical Trial Phase 1 study, sponsored by Johns Hopkins University.
NCT00952601 is a Phase 1 study that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00952601, a Phase 1 study, was terminated before completion, sponsored by Johns Hopkins University.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
Pharmacotherapy has long been considered the primary approach for tic suppression in Tourette syndrome (TS). Unfortunately, medications are often ineffective and frequently have significant side-effects. This is a pilot therapeutic study using a dietary approach, the modified Atkins diet (MAD). The goal of this study is to establish the safety, tolerability, and efficacy of dietary therapy in patients with TS ("proof of concept") and to determine whether this intervention is worthy of evaluation in large-scale clinical trials. The modified Atkins diet mimics the well established ketogenic diet, but in a less-restrictive dietary manner. Dietary approaches using the MAD/ketogenic diet are currently under investigation for neurological conditions other than epilepsy, including Alzheimer disease, headaches, autism, narcolepsy, brain tumors, traumatic brain injury, Parkinson's disease, and depression.
Primary Outcome
Number of tics per day, intensity, severity, will be compared to baseline (pre-diet)
Interventions
- DIETARY_SUPPLEMENT Modified Atkins diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2008-09 |
| Est. Completion | 2010-07 |
| Phase | Phase 1 |
Why NCT00952601 stopped before completion
NCT00952601 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 1 intervention - of which Modified Atkins diet is the first listed.
NCT00952601 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00952601 about?
NCT00952601 is a clinical study titled "Pilot Study of the Modified Atkins Diet for Tourette Syndrome". Pharmacotherapy has long been considered the primary approach for tic suppression in Tourette syndrome (TS). Unfortunately, medications are often ineffective and frequently have significant side-effects. This is a pilot therapeutic study using a dietary approach, the modified Atkins diet (MAD). The ...
What is the current status of trial NCT00952601?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2008-09. Estimated completion is 2010-07.
What interventions are being tested in trial NCT00952601?
The interventions under investigation include: Modified Atkins diet (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00952601?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00952601's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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