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NCT00927459 · ClinicalTrials.gov registry record · Phase 1
Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Liposomal siRNA in Subjects With High Cholesterol
A Phase 1 study, sponsored by Arbutus Biopharma Corporation.
- Terminated
- Registry status
- Phase 1
- Development phase
- 23
- Enrollment target
NCT00927459: Clinical Trial Phase 1 study, sponsored by Arbutus Biopharma Corporation.
NCT00927459 is a Phase 1 study that was terminated before completion, run by Arbutus Biopharma Corporation. The registered enrollment target is 23 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00927459, a Phase 1 study, was terminated before completion, sponsored by Arbutus Biopharma Corporation.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 23 participants
- Enrollment target
Study Summary
This study is a Phase 1, single-center, placebo-controlled, single-blind, first-in-human, single-ascending dose study in male and female subjects with high cholesterol. A maximum of 32 subjects is planned for enrollment in this study.
Interventions
- DRUG Placebo
- DRUG PRO-040201
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2009-06 |
| Est. Completion | 2010-01 |
| Phase | Phase 1 |
Why NCT00927459 stopped before completion
NCT00927459 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00927459 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00927459 about?
NCT00927459 is a clinical study titled "Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Liposomal siRNA in Subjects With High Cholesterol". This study is a Phase 1, single-center, placebo-controlled, single-blind, first-in-human, single-ascending dose study in male and female subjects with high cholesterol. A maximum of 32 subjects is planned for enrollment in this study.
What is the current status of trial NCT00927459?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2009-06. Estimated completion is 2010-01.
What interventions are being tested in trial NCT00927459?
The interventions under investigation include: Placebo (DRUG), PRO-040201 (DRUG).
Who is sponsoring clinical trial NCT00927459?
This trial is sponsored by Arbutus Biopharma Corporation, which has 7 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00927459's enrollment target sits among peer trials
23 1596th of 2000 higher than 400 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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