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NCT00903708 · ClinicalTrials.gov registry record · Phase 1
LY2275796 in Advanced Cancer
A Phase 1 study, sponsored by M.D. Anderson Cancer Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
NCT00903708: Completed Phase 1 study, sponsored by M.D. Anderson Cancer Center.
NCT00903708 is a Phase 1 study that has completed, run by M.D. Anderson Cancer Center. The registered enrollment target is 24 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (60% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00903708, a Phase 1 study, has completed, sponsored by M.D. Anderson Cancer Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
Study Summary
Primary Objective: * To determine a recommended Phase 2 dose of LY2275796 that may be safely administered to patients with advanced cancer, with prospects for therapeutic biologic effects. This will require simultaneous: * monitoring of toxicities \& determination of maximal tolerated dose (MTD) * detecting eIF-4E target inhibition in tumor * pharmacokinetic measurements Secondary Objectives: * To estimate pharmacokinetic parameters of LY2275796 and explore pharmacokinetic/pharmacodynamic relationships * To document any antitumor activity observed with LY2275796
Primary Outcome
Maximum tolerated dose (MTD) defined as highest dose at which 0-1/6 patients experience Grade III toxicity with LY2275796 administered IV as a loading dose daily over 3 days, then as maintenance dose weekly.
Interventions
- DRUG LY2275796
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2006-09 |
| Est. Completion | 2010-06 |
| Phase | Phase 1 |
What the finished NCT00903708 record still lists
NCT00903708 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (60% lower).
The record links to 0 conditions, and to 1 intervention - of which LY2275796 is the first listed.
NCT00903708 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00903708 about?
NCT00903708 is a clinical study titled "LY2275796 in Advanced Cancer". Primary Objective: * To determine a recommended Phase 2 dose of LY2275796 that may be safely administered to patients with advanced cancer, with prospects for therapeutic biologic effects. This will require simultaneous: * monitoring of toxicities \& determination of maximal tolerated dose (MTD) * ...
What is the current status of trial NCT00903708?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2006-09. Estimated completion is 2010-06.
What interventions are being tested in trial NCT00903708?
The interventions under investigation include: LY2275796 (DRUG).
Who is sponsoring clinical trial NCT00903708?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00903708's enrollment target sits among peer trials
24 1520th of 2000 higher than 405 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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