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NCT00891995 · ClinicalTrials.gov registry record · Phase 2
Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes
A Phase 2 study, sponsored by Jaeb Center for Health Research.
- Terminated
- Registry status
- Phase 2
- Development phase
- 71
- Enrollment target
NCT00891995: Clinical Trial Phase 2 study, sponsored by Jaeb Center for Health Research.
NCT00891995 is a Phase 2 study that was terminated before completion, run by Jaeb Center for Health Research. The registered enrollment target is 71 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (47% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00891995, a Phase 2 study, was terminated before completion, sponsored by Jaeb Center for Health Research.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 71 participants
- Enrollment target
Study Summary
The purpose of this study is to find out if very tight blood glucose control from the onset of Type 1 Diabetes can preserve beta cell function. Study subjects will be randomly assigned to receive either standard diabetes management or intensive diabetes management, which involves several days of closed loop therapy followed by home use of a continuous glucose monitor and insulin pump.
Primary Outcome
In the primary analysis of the 12-month Mixed-Meal Tolerance Test (MMTT) results, the geometric mean (95% C.I.) of C-peptide average AUC (=AUC/time) was 0.43 (0.34, 0.52) pmol/ml in the intensive treatment group and 0.52 (0.32, 0.75) pmol/ml in the usual care group (P=0.49).
Interventions
- DEVICE Continuous glucose monitor
- DEVICE Closed loop
- DEVICE Home glucose monitoring
- DEVICE Insulin pump
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 71 participants |
| Start Date | 2010-09 |
| Est. Completion | 2013-10 |
| Phase | Phase 2 |
Why NCT00891995 stopped before completion
NCT00891995 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 71 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (47% lower).
The record links to 0 conditions, and to 4 interventions - of which Continuous glucose monitor is the first listed.
NCT00891995 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00891995 about?
NCT00891995 is a clinical study titled "Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes". The purpose of this study is to find out if very tight blood glucose control from the onset of Type 1 Diabetes can preserve beta cell function. Study subjects will be randomly assigned to receive either standard diabetes management or intensive diabetes management, which involves several days of clo...
What is the current status of trial NCT00891995?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 71 participants. The study started on 2010-09. Estimated completion is 2013-10.
What interventions are being tested in trial NCT00891995?
The interventions under investigation include: Continuous glucose monitor (DEVICE), Closed loop (DEVICE), Home glucose monitoring (DEVICE), Insulin pump (DEVICE).
Who is sponsoring clinical trial NCT00891995?
This trial is sponsored by Jaeb Center for Health Research, which has 119 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00891995's enrollment target sits among peer trials
71 936th of 2000 higher than 1,064 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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