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NCT00891592 · ClinicalTrials.gov registry record · Phase 1
Umbilical Cord Blood Transplant for Hematological Malignancies
A Phase 1 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 1
- Development phase
- 5
- Enrollment target
NCT00891592: Completed Phase 1 study, sponsored by University of Pennsylvania.
NCT00891592 is a Phase 1 study that has completed, run by University of Pennsylvania. The registered enrollment target is 5 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00891592, a Phase 1 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
This protocol will enroll subjects with advanced hematologic malignancies who do not have a suitable related or unrelated donor to undergo a Stem Cell Transplant. In this study, subjects will undergo a Stem Cell Transplant using Cord Blood. Part of the cord blood will be used for the Stem Cell Transplant and part of the cord blood will be sent to a laboratory in order to grow the T cells (from the cord blood) and increase the activity of the cord blood T cells. The purpose of this part of the study is to see if it is safe to give study subjects activated T cells made from a small portion of their donor UCB unit immediately after the UCB transplant. Activated T cells have been used safely in stem cell transplantation studies in the past, but they have never been studied UCB transplantation.
Interventions
- BIOLOGICAL Ex Vivo CD3/CD28 costimulated Umbilical Cord Blood T cells
- OTHER Observation Arm
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2009-01 |
| Est. Completion | 2016-05 |
| Phase | Phase 1 |
What the finished NCT00891592 record still lists
NCT00891592 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 2 interventions - of which Ex Vivo CD3/CD28 costimulated Umbilical Cord Blood T cells is the first listed.
NCT00891592 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00891592 about?
NCT00891592 is a clinical study titled "Umbilical Cord Blood Transplant for Hematological Malignancies". This protocol will enroll subjects with advanced hematologic malignancies who do not have a suitable related or unrelated donor to undergo a Stem Cell Transplant. In this study, subjects will undergo a Stem Cell Transplant using Cord Blood. Part of the cord blood will be used for the Stem Cell Tran...
What is the current status of trial NCT00891592?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 5 participants. The study started on 2009-01. Estimated completion is 2016-05.
What interventions are being tested in trial NCT00891592?
The interventions under investigation include: Ex Vivo CD3/CD28 costimulated Umbilical Cord Blood T cells (BIOLOGICAL), Observation Arm (OTHER).
Who is sponsoring clinical trial NCT00891592?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00891592's enrollment target sits among peer trials
5 1989th of 2000 higher than 6 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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