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NCT00869544 · ClinicalTrials.gov registry record
Pneumocystis in Pathogenesis of HIV-associated Emphysema
A clinical trial, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 250
- Enrollment target
NCT00869544: Completed study, sponsored by University of Pittsburgh.
NCT00869544 is a clinical trial that has completed, run by University of Pittsburgh. The registered enrollment target is 250 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00869544 has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 250 participants
- Enrollment target
Study Summary
A. Statement of Hypotheses: HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected smokers, and it has been hypothesized that this accelerated disease progression is the result of one or more latent infections that amplifies the pulmonary inflammatory response to cigarette smoke. Pneumocystis is one infectious agent that likely plays a key role in the development of HIV-associated emphysema. Colonization with Pneumocystis has been demonstrated in HIV-infected subjects, and HIV-infected smokers are particularly susceptible to Pc colonization regardless of CD4 cell count or use of prophylaxis. Pneumocystis colonization is also increased in non-HIV-infected patients with chronic obstructive pulmonary disease (COPD) and is directly related to the severity of the disease. The presence of Pneumocystis in the lungs, even at low levels as seen in colonization, produces inflammatory changes similar to those seen in COPD, with increases in the numbers of neutrophils and cytotoxic CD8+ lymphocytes. We propose that Pneumocystis accelerates emphysema in HIV-infected smokers by stimulating inflammation and tissue destruction. We will examine the role of co-infection with Pneumocystis in the pathogenesis of HIV-associated emphysema and the mechanism by which it causes emphysema progression. These studies will lead to information that will provide a rational basis for prevention and therapy of HIV-associated emphysema and provide a model for emphysema in the general population
Primary Outcome
The main endpoints that will be assessed are the extent of Pc colonization in this population and its relationship to lung function, inflammatory cells and cytokines, and proteases.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2007-08 |
| Est. Completion | 2013-07 |
What the finished NCT00869544 record still lists
NCT00869544 is an observational study that tracks outcomes without assigning an intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00869544 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00869544 about?
NCT00869544 is a clinical study titled "Pneumocystis in Pathogenesis of HIV-associated Emphysema". A. Statement of Hypotheses: HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected smokers, and it has been hypothesized that this accelerated disease progression is the result of one or more latent infections that amplifies the pulmonary inflammatory response t...
What is the current status of trial NCT00869544?
This trial is currently completed. The enrollment target is 250 participants. The study started on 2007-08. Estimated completion is 2013-07.
Who is sponsoring clinical trial NCT00869544?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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