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NCT00858273 · ClinicalTrials.gov registry record · NA
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B
A NA study, sponsored by Nemours Children's Clinic.
- Completed
- Registry status
- NA
- Development phase
- 41
- Enrollment target
NCT00858273 is a NA study that has completed, run by Nemours Children's Clinic. The registered enrollment target is 41 participants.
The verdict
NCT00858273, a NA study, has completed, sponsored by Nemours Children's Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
Study Summary
Glutathione is normally present at high levels in the blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by several reactive oxygen species produced by the metabolism of most nutrients, including glucose. Glutathione is a small peptide made from 3 amino acids, glutamate, cysteine, and glycine. This study is looking at how blood sugar levels may affect the way glutathione is made and used by the body. Since glutathione is continuously synthesized and broken down, the amount of glutathione present in the blood depends on the balance between its rate of synthesis and its rate of use. In earlier studies, we found that in poorly controlled diabetic teenagers, glutathione was low, not because it was not produced fast enough, but because it was used at an excessive rate. In this study, we want to find out whether improving blood sugar control will increase glutathione levels, and, if so, how long this will take. We also hope to find out if oral supplementation with a mixture of several antioxidant vitamins and minerals will increase glutathione levels more than taking a placebo.
Interventions
- DRUG Regular Insulin
- DIETARY_SUPPLEMENT Antioxidant supplement
- OTHER Diabetes treatment
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2008-03 |
| Est. Completion | 2011-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00858273
The ClinicalTrials.gov registry entry for NCT00858273 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 41 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nemours Children's Clinic, which has 108 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Regular Insulin is the first listed.
NCT00858273 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00858273 about?
NCT00858273 is a clinical study titled "Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B". Glutathione is normally present at high levels in the blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by several reactive oxygen species produced by the metabolism of most nutrients, including glucose. Glutathione is a ...
What is the current status of trial NCT00858273?
This trial is currently completed. It is a NA study. The enrollment target is 41 participants. The study started on 2008-03. Estimated completion is 2011-08.
What interventions are being tested in trial NCT00858273?
The interventions under investigation include: Regular Insulin (DRUG), Antioxidant supplement (DIETARY_SUPPLEMENT), Diabetes treatment (OTHER).
Who is sponsoring clinical trial NCT00858273?
This trial is sponsored by Nemours Children's Clinic, which has 108 total clinical trials registered on ClinicalTrials.gov.
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