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NCT00849472 · ClinicalTrials.gov registry record · Phase 2
Treatment With Pazopanib for Neoadjuvant Breast Cancer
A Phase 2 study, sponsored by GlaxoSmithKline.
- Completed
- Registry status
- Phase 2
- Development phase
- 101
- Enrollment target
NCT00849472: Completed Phase 2 study, sponsored by GlaxoSmithKline.
NCT00849472 is a Phase 2 study that has completed, run by GlaxoSmithKline. The registered enrollment target is 101 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (24% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00849472, a Phase 2 study, has completed, sponsored by GlaxoSmithKline.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 101 participants
- Enrollment target
Study Summary
The purpose of this study is to determine whether the treatment of a doxorubicin in combination with cyclophosphamide followed by a combination of pazopanib in combination with paclitaxel prior to surgery results in a pathological complete response in females with breast cancer.
Primary Outcome
pCR was defined as no histologic evidence of invasive tumor cells in the surgical breast specimen, axillary nodes, or sentinel node identified after neoadjuvant chemotherapy.
Interventions
- PROCEDURE surgery
- DRUG doxorubicin + cyclophosphamide
- DRUG paclitaxel + pazopanib
- DRUG pazopanib monotherapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 101 participants |
| Start Date | 2009-07 |
| Est. Completion | 2013-04 |
| Phase | Phase 2 |
What the finished NCT00849472 record still lists
NCT00849472 is an interventional study that assigns participants to a tested intervention. The registered 101 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (24% lower).
The record links to 0 conditions, and to 4 interventions - of which surgery is the first listed.
NCT00849472 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00849472 about?
NCT00849472 is a clinical study titled "Treatment With Pazopanib for Neoadjuvant Breast Cancer". The purpose of this study is to determine whether the treatment of a doxorubicin in combination with cyclophosphamide followed by a combination of pazopanib in combination with paclitaxel prior to surgery results in a pathological complete response in females with breast cancer.
What is the current status of trial NCT00849472?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 101 participants. The study started on 2009-07. Estimated completion is 2013-04.
What interventions are being tested in trial NCT00849472?
The interventions under investigation include: surgery (PROCEDURE), doxorubicin + cyclophosphamide (DRUG), paclitaxel + pazopanib (DRUG), pazopanib monotherapy (DRUG).
Who is sponsoring clinical trial NCT00849472?
This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00849472's enrollment target sits among peer trials
101 672nd of 2000 higher than 1,329 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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