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NCT00837590 · ClinicalTrials.gov registry record · Phase 1
Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls
A Phase 1 study, sponsored by Indiana University.
- Terminated
- Registry status
- Phase 1
- Development phase
- 16
- Enrollment target
NCT00837590: Clinical Trial Phase 1 study, sponsored by Indiana University.
NCT00837590 is a Phase 1 study that was terminated before completion, run by Indiana University. The registered enrollment target is 16 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00837590, a Phase 1 study, was terminated before completion, sponsored by Indiana University.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 16 participants
- Enrollment target
Study Summary
Aims: 1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic dysfunction in human pre-diabetic obesity? 2. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in the context of existing treatment with metformin? 3. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in the context of existing treatment with lisinopril?
Primary Outcome
The primary endpoints of interest is flow-mediated vasodilation
Interventions
- DRUG Chronic salsalate
- DRUG Acute Salsalate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2009-03 |
| Est. Completion | 2010-08 |
| Phase | Phase 1 |
Why NCT00837590 stopped before completion
NCT00837590 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower).
The record links to 0 conditions, and to 2 interventions - of which Chronic salsalate is the first listed.
NCT00837590 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00837590 about?
NCT00837590 is a clinical study titled "Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls". Aims: 1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic dysfunction in human pre-diabetic obesity? 2. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in the context of existing treatment with metformin? 3. Are there bene...
What is the current status of trial NCT00837590?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 16 participants. The study started on 2009-03. Estimated completion is 2010-08.
What interventions are being tested in trial NCT00837590?
The interventions under investigation include: Chronic salsalate (DRUG), Acute Salsalate (DRUG).
Who is sponsoring clinical trial NCT00837590?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00837590's enrollment target sits among peer trials
16 1786th of 2000 higher than 203 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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