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NCT00825344 · ClinicalTrials.gov registry record · NA
Preoperative Etanercept Before Inguinal Hernia Surgery
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 77
- Enrollment target
NCT00825344: Completed NA study, sponsored by Johns Hopkins University.
NCT00825344 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 77 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00825344, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 77 participants
- Enrollment target
Study Summary
Inguinal hernia repair is one of the most frequently performed operations in young men. Persistent pain after inguinal surgery represents a significant cause of disability, occurring in between 15%-35% of cases. In a majority of these patients, their groin pain persisted after a previous hernia repair. The main type of chronic postsurgical pain is neuropathic, caused by injured nerves. One of the principal components in the pathophysiology of postsurgical pain is cytokines, specifically tumor necrosis factor (TNF). In animal studies, injecting TNF inhibitors before nerve injury can reduce pain behaviors and neuropathology. Finding a way to reduce the incidence of postsurgical pain after hernia repair could enhance function, and reduce the need for opioids and other analgesics. The investigators intend to conduct the first randomized, controlled study evaluating whether preemptive administration of a tumor necrosis inhibitor can reduce postoperative pain and opioid consumption after hernia repair. This is important because the degree and intensity of postsurgical pain is a major predictor for the development of chronic postsurgical pain.
Interventions
- DRUG Saline
- DRUG Etanercept
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 77 participants |
| Start Date | 2009-01 |
| Est. Completion | 2012-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00825344
The ClinicalTrials.gov registry entry for NCT00825344 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 77 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Saline is the first listed.
NCT00825344 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00825344 about?
NCT00825344 is a clinical study titled "Preoperative Etanercept Before Inguinal Hernia Surgery". Inguinal hernia repair is one of the most frequently performed operations in young men. Persistent pain after inguinal surgery represents a significant cause of disability, occurring in between 15%-35% of cases. In a majority of these patients, their groin pain persisted after a previous hernia repa...
What is the current status of trial NCT00825344?
This trial is currently completed. It is a NA study. The enrollment target is 77 participants. The study started on 2009-01. Estimated completion is 2012-08.
What interventions are being tested in trial NCT00825344?
The interventions under investigation include: Saline (DRUG), Etanercept (DRUG).
Who is sponsoring clinical trial NCT00825344?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
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