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NCT00802204 · ClinicalTrials.gov registry record · NA
Dopamine and Insulin Resistance
A NA study of Obesity, sponsored by Vanderbilt University.
- Completed
- Registry status
- NA
- Development phase
- 28
- Enrollment target
- 1
- Study location
NCT00802204: Completed NA study of Obesity, sponsored by Vanderbilt University.
NCT00802204 is a NA study of Obesity that has completed, run by Vanderbilt University. The registered enrollment target is 28 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00802204, a NA study of Obesity, has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- NA
- Development phase
- 28 participants
- Enrollment target
- 1
- Study location
Study Summary
Obese individuals have fewer striatal dopamine type 2 receptors (DRD2) than normal weight individuals. Lower DRD2 levels are associated with addiction and a decreased sense of pleasure.Obesity is also associated with insulin resistance (poor insulin action).We propose that insulin resistance and low DRD2 are associated. Using PET imaging,we aim to determine DRD2 binding potential (BP) in the brain is associated with insulin resistance and neuroendocrine hormone levels. Obese participants will be compared to lean, gender and age similar participants. We also aim to determine the effect of caloric restriction on DRD2 BP in obese subjects
Primary Outcome
Region of interest compared to reference region to calculate binding potential
Conditions Studied
Interventions
- PROCEDURE MRI
- RADIATION PET scan
- PROCEDURE Oral glucose tolerance test
- BEHAVIORAL Psychological scales to assess attitudes and behaviors related to eating and quality of life
- OTHER Caloric Restriction
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2008-12 |
| Est. Completion | 2012-12 |
| Phase | NA |
What the finished NCT00802204 record still lists
NCT00802204 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 5 interventions - of which MRI is the first listed.
NCT00802204 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT00802204 about?
NCT00802204 is a clinical study titled "Dopamine and Insulin Resistance". Obese individuals have fewer striatal dopamine type 2 receptors (DRD2) than normal weight individuals. Lower DRD2 levels are associated with addiction and a decreased sense of pleasure.Obesity is also associated with insulin resistance (poor insulin action).We propose that insulin resistance and low...
What is the current status of trial NCT00802204?
This trial is currently completed. It is a NA study. The enrollment target is 28 participants. The study started on 2008-12. Estimated completion is 2012-12.
What conditions does trial NCT00802204 study?
This clinical trial studies the following conditions: Obesity.
What interventions are being tested in trial NCT00802204?
The interventions under investigation include: MRI (PROCEDURE), PET scan (RADIATION), Oral glucose tolerance test (PROCEDURE), Psychological scales to assess attitudes and behaviors related to eating and quality of life (BEHAVIORAL), Caloric Restriction (OTHER).
Who is sponsoring clinical trial NCT00802204?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00802204 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00802204's enrollment target sits among peer trials
28 886th of 1053 higher than 162 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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