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NCT00791648 · ClinicalTrials.gov registry record · NA
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
A NA study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 653
- Enrollment target
NCT00791648: Completed NA study, sponsored by Vanderbilt University Medical Center.
NCT00791648 is a NA study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 653 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (53% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00791648, a NA study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 653 participants
- Enrollment target
Study Summary
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following cardiac surgery. 2. postoperative delirium following cardiac surgery. Aim1b: Patients using statins preoperatively will be randomized to atorvastatin 80mg or placebo on day of surgery and 40mg or placebo on postop day 1 with resumption of preoperative statin therapy on postop day 2 to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following cardiac surgery. 2. postoperative delirium following cardiac surgery. Endpoints include glomerular filtration, urine and plasma markers of renal dysfunction, markers of oxidative stress, mitochondrial function, systemic inflammatory markers, delirium, dialysis, stroke, myocardial infarction, time to extubation, ICU length of stay, and death.
Interventions
- DRUG placebo
- DRUG atorvastatin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 653 participants |
| Start Date | 2009-07 |
| Est. Completion | 2014-12 |
| Phase | NA |
What the finished NCT00791648 record still lists
NCT00791648 is an interventional study that assigns participants to a tested intervention. The registered 653 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (53% lower).
The record links to 0 conditions, and to 2 interventions - of which placebo is the first listed.
NCT00791648 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00791648 about?
NCT00791648 is a clinical study titled "Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery". Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following card...
What is the current status of trial NCT00791648?
This trial is currently completed. It is a NA study. The enrollment target is 653 participants. The study started on 2009-07. Estimated completion is 2014-12.
What interventions are being tested in trial NCT00791648?
The interventions under investigation include: placebo (DRUG), atorvastatin (DRUG).
Who is sponsoring clinical trial NCT00791648?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00791648's enrollment target sits among peer trials
653 156th of 2000 higher than 1,845 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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