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NCT00791648 · ClinicalTrials.gov registry record · NA
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
A NA study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 653
- Enrollment target
NCT00791648 is a NA study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 653 participants.
The verdict
NCT00791648, a NA study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 653 participants
- Enrollment target
Study Summary
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following cardiac surgery. 2. postoperative delirium following cardiac surgery. Aim1b: Patients using statins preoperatively will be randomized to atorvastatin 80mg or placebo on day of surgery and 40mg or placebo on postop day 1 with resumption of preoperative statin therapy on postop day 2 to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following cardiac surgery. 2. postoperative delirium following cardiac surgery. Endpoints include glomerular filtration, urine and plasma markers of renal dysfunction, markers of oxidative stress, mitochondrial function, systemic inflammatory markers, delirium, dialysis, stroke, myocardial infarction, time to extubation, ICU length of stay, and death.
Interventions
- DRUG placebo
- DRUG atorvastatin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 653 participants |
| Start Date | 2009-07 |
| Est. Completion | 2014-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00791648
The ClinicalTrials.gov registry entry for NCT00791648 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 653 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which placebo is the first listed.
NCT00791648 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00791648 about?
NCT00791648 is a clinical study titled "Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery". Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that short-term atorvastatin use decreases: 1. acute kidney injury following card...
What is the current status of trial NCT00791648?
This trial is currently completed. It is a NA study. The enrollment target is 653 participants. The study started on 2009-07. Estimated completion is 2014-12.
What interventions are being tested in trial NCT00791648?
The interventions under investigation include: placebo (DRUG), atorvastatin (DRUG).
Who is sponsoring clinical trial NCT00791648?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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