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NCT00771901 · ClinicalTrials.gov registry record · NA
Effect of Endoplasmic Reticulum Stress on Metabolic Function
A NA study, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- NA
- Development phase
- 101
- Enrollment target
NCT00771901: Completed NA study, sponsored by Washington University School of Medicine.
NCT00771901 is a NA study that has completed, run by Washington University School of Medicine. The registered enrollment target is 101 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00771901, a NA study, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 101 participants
- Enrollment target
Study Summary
Normally, the hormone insulin works to help keep blood sugar normal. However, as a person gains weight, insulin does not work as well and blood sugar tends to be a little higher than normal. This is called "insulin resistance". Two investigational drugs (not approved by the Food and Drug Administration) for the treatment of high lipid levels or insulin resistance are being examined in this study: one drug is called tauroursodeoxycholic acid (TUDCA), the other is called sodium phenylbutyrate (PBA). This study is designed to test if TUDCA and/or PBA is effective in people who are obese with insulin resistance and high lipids. We hypothesize that pharmacologically-induced decreases in ER stress will improve insulin action and hepatic lipid metabolism in obese subjects.
Primary Outcome
Fat mass (%)
Interventions
- OTHER placebo
- DRUG sodium phenylbutyrate
- DRUG tauroursodeoxycholic acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 101 participants |
| Start Date | 2008-02 |
| Est. Completion | 2014-12 |
| Phase | NA |
What the finished NCT00771901 record still lists
NCT00771901 is an interventional study that assigns participants to a tested intervention. The registered 101 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 3 interventions - of which placebo is the first listed.
NCT00771901 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00771901 about?
NCT00771901 is a clinical study titled "Effect of Endoplasmic Reticulum Stress on Metabolic Function". Normally, the hormone insulin works to help keep blood sugar normal. However, as a person gains weight, insulin does not work as well and blood sugar tends to be a little higher than normal. This is called "insulin resistance". Two investigational drugs (not approved by the Food and Drug Administra...
What is the current status of trial NCT00771901?
This trial is currently completed. It is a NA study. The enrollment target is 101 participants. The study started on 2008-02. Estimated completion is 2014-12.
What interventions are being tested in trial NCT00771901?
The interventions under investigation include: placebo (OTHER), sodium phenylbutyrate (DRUG), tauroursodeoxycholic acid (DRUG).
Who is sponsoring clinical trial NCT00771901?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00771901's enrollment target sits among peer trials
101 840th of 2000 higher than 1,161 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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