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NCT00765544 · ClinicalTrials.gov registry record · Phase 1
Targeted Lower Extremity Joint Training
A Phase 1 study, sponsored by US Department of Veterans Affairs.
- Terminated
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
NCT00765544: Clinical Trial Phase 1 study, sponsored by US Department of Veterans Affairs.
NCT00765544 is a Phase 1 study that was terminated before completion, run by US Department of Veterans Affairs. The registered enrollment target is 10 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00765544, a Phase 1 study, was terminated before completion, sponsored by US Department of Veterans Affairs.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
Study Summary
The presence of foot drop limits normal gait. Our prior data has suggested that approximately 30% of MS patients have foot drop. Although we have observed that "task-specific" rehabilitation using the Lokomat can improve ambulation in chronic MS patients, subjects with "foot drop" have difficulty translating task-specific training to normative gait patterns over ground, despite improving speed and endurance. One of the key limitations of the Lokomat is a lack of robot-assisted training for the ankle joint. The Anklebot, an MIT-developed rehabilitation robot for the ankle, has the potential to address this. The device can move throughout three planes and train ankle flexion, extension, inversion and eversion; however, therapy with the Anklebot alone does not train the knee or hip. We plan to test whether subject foot drop and overall gait benefit more from Anklebot therapy alone or a combination of Anklebot and Lokomat.
Interventions
- DEVICE Lokomat
- DEVICE Anklebot
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2008-09 |
| Est. Completion | 2008-09 |
| Phase | Phase 1 |
Why NCT00765544 stopped before completion
NCT00765544 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 2 interventions - of which Lokomat is the first listed.
NCT00765544 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00765544 about?
NCT00765544 is a clinical study titled "Targeted Lower Extremity Joint Training". The presence of foot drop limits normal gait. Our prior data has suggested that approximately 30% of MS patients have foot drop. Although we have observed that "task-specific" rehabilitation using the Lokomat can improve ambulation in chronic MS patients, subjects with "foot drop" have difficulty tr...
What is the current status of trial NCT00765544?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2008-09. Estimated completion is 2008-09.
What interventions are being tested in trial NCT00765544?
The interventions under investigation include: Lokomat (DEVICE), Anklebot (DEVICE).
Who is sponsoring clinical trial NCT00765544?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00765544's enrollment target sits among peer trials
10 1913th of 2000 higher than 46 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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