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NCT00760383 · ClinicalTrials.gov registry record · NA
Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation
A NA study, sponsored by University of Oregon.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT00760383 is a NA study that has completed, run by University of Oregon. The registered enrollment target is 60 participants.
The verdict
NCT00760383, a NA study, has completed, sponsored by University of Oregon.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
The general hypothesis is that in older adults muscle regrowth after an acute musculoskeletal stress will be positively influenced by traditional physical rehabilitation, and further enhanced by nutritional supplementation. Using state-of-the-art stable isotope methodologies for the study of muscle metabolism and methodologies for the measurement of cell signaling, we will test the following specific hypotheses: 1) Total knee arthroplasty (TKA) induces an acute net protein catabolism mainly by reducing muscle protein synthesis; 2) TKA induced catabolism is attenuated by the ingestion of essential amino acids (EAA); 3) EAA supplementation in combination with physical therapy (PT) will stimulate muscle protein synthesis and mTOR signaling to a greater extent than PT with Placebo; and 4) EAA supplementation during TKA PT rehabilitation will improve muscle strength, muscle volume and functional outcomes to a greater extent than PT with Placebo. Public Benefit: This research will focus rehabilitation efforts on specific and currently unresolved mechanisms responsible for muscle loss following total knee replacement in older adults. While knee pain due to bone arthritis is often alleviated after knee replacement, complete return of physical function and independence is difficult to achieve. This research will help to restore physical function and independence in the rapidly growing population of older adults with knee arthritis.
Interventions
- DIETARY_SUPPLEMENT Alanine
- DIETARY_SUPPLEMENT Essential amino acids
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2008-06 |
| Est. Completion | 2013-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00760383
The ClinicalTrials.gov registry entry for NCT00760383 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Oregon, which has 63 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Alanine is the first listed.
NCT00760383 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00760383 about?
NCT00760383 is a clinical study titled "Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation". The general hypothesis is that in older adults muscle regrowth after an acute musculoskeletal stress will be positively influenced by traditional physical rehabilitation, and further enhanced by nutritional supplementation. Using state-of-the-art stable isotope methodologies for the study of muscle ...
What is the current status of trial NCT00760383?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2008-06. Estimated completion is 2013-12.
What interventions are being tested in trial NCT00760383?
The interventions under investigation include: Alanine (DIETARY_SUPPLEMENT), Essential amino acids (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00760383?
This trial is sponsored by University of Oregon, which has 63 total clinical trials registered on ClinicalTrials.gov.
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