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NCT00756847 · ClinicalTrials.gov registry record · Phase 1
Safety Study of XL147 (SAR245408), in Combination With Paclitaxel and Carboplatin in Adults With Solid Tumors
A Phase 1 study, sponsored by Sanofi.
- Completed
- Registry status
- Phase 1
- Development phase
- 52
- Enrollment target
NCT00756847: Completed Phase 1 study, sponsored by Sanofi.
NCT00756847 is a Phase 1 study that has completed, run by Sanofi. The registered enrollment target is 52 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00756847, a Phase 1 study, has completed, sponsored by Sanofi.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 52 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate the safety and tolerability of XL147 in combination with paclitaxel and carboplatin in adults with solid tumors. XL147 is a new chemical entity that inhibits PI3 Kinase. Inactivation of PI3K has been shown to inhibit growth and induce apoptosis (programmed cell death) in tumor cells. In clinical practice, the combination of paclitaxel and carboplatin is an accepted treatment regimen for various solid tumors, including ovarian cancer, endometrial cancer and non-small cell lung cancer (NSCLC).
Interventions
- DRUG carboplatin
- DRUG paclitaxel
- DRUG XL147 (SAR245408),
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2008-09 |
| Est. Completion | 2012-10 |
| Phase | Phase 1 |
What the finished NCT00756847 record still lists
NCT00756847 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 52 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower).
The record links to 0 conditions, and to 3 interventions - of which carboplatin is the first listed.
NCT00756847 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00756847 about?
NCT00756847 is a clinical study titled "Safety Study of XL147 (SAR245408), in Combination With Paclitaxel and Carboplatin in Adults With Solid Tumors". The purpose of this study is to evaluate the safety and tolerability of XL147 in combination with paclitaxel and carboplatin in adults with solid tumors. XL147 is a new chemical entity that inhibits PI3 Kinase. Inactivation of PI3K has been shown to inhibit growth and induce apoptosis (programmed ce...
What is the current status of trial NCT00756847?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 52 participants. The study started on 2008-09. Estimated completion is 2012-10.
What interventions are being tested in trial NCT00756847?
The interventions under investigation include: carboplatin (DRUG), paclitaxel (DRUG), XL147 (SAR245408), (DRUG).
Who is sponsoring clinical trial NCT00756847?
This trial is sponsored by Sanofi, which has 713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00756847's enrollment target sits among peer trials
52 956th of 2000 higher than 1,032 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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