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NCT00750204 · ClinicalTrials.gov registry record · NA
Airway Pressure Release Ventilation in Acute Lung Injury
A NA study, sponsored by Johns Hopkins University.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT00750204: Clinical Trial NA study, sponsored by Johns Hopkins University.
NCT00750204 is a NA study that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 2 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00750204, a NA study, was terminated before completion, sponsored by Johns Hopkins University.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and requirements for sedative medications. We will also compare markers of inflammation in the blood and lung to determine if APRV reduces ventilator-induced lung injury (VILI), compared to conventional mechanical ventilation. The proposed study is a randomized, crossover trial. We plan to enroll 40 patients with ALI and randomize to APRV or conventional MV for 24 hours. After this time the patients will be switched to the alternative mode of ventilation (MV or APRV) for another 24 hours. To assess breathing comfort, at the end of each 24-hour period we will measure the amounts of sedative and analgesic medications used. We will also measure the concentrations of markers of inflammation in the blood and lung as measures of VILI. Finally, throughout the study we will compare the adequacy of gas exchange with APRV compared to conventional MV.
Interventions
- DEVICE APRV
- DEVICE Conventional MV
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2008-07 |
| Est. Completion | 2008-10-15 |
| Phase | NA |
Why NCT00750204 stopped before completion
NCT00750204 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which APRV is the first listed.
NCT00750204 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00750204 about?
NCT00750204 is a clinical study titled "Airway Pressure Release Ventilation in Acute Lung Injury". The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and requirements for sedative medications. We will also compare markers of infl...
What is the current status of trial NCT00750204?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2008-07. Estimated completion is 2008-10-15.
What interventions are being tested in trial NCT00750204?
The interventions under investigation include: APRV (DEVICE), Conventional MV (DEVICE).
Who is sponsoring clinical trial NCT00750204?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00750204's enrollment target sits among peer trials
2 1997th of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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