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NCT00750204 · ClinicalTrials.gov registry record · NA
Airway Pressure Release Ventilation in Acute Lung Injury
A NA study, sponsored by Johns Hopkins University.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT00750204: Clinical Trial NA study, sponsored by Johns Hopkins University.
NCT00750204 is a NA study that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 2 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00750204, a NA study, was terminated before completion, sponsored by Johns Hopkins University.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and requirements for sedative medications. We will also compare markers of inflammation in the blood and lung to determine if APRV reduces ventilator-induced lung injury (VILI), compared to conventional mechanical ventilation. The proposed study is a randomized, crossover trial. We plan to enroll 40 patients with ALI and randomize to APRV or conventional MV for 24 hours. After this time the patients will be switched to the alternative mode of ventilation (MV or APRV) for another 24 hours. To assess breathing comfort, at the end of each 24-hour period we will measure the amounts of sedative and analgesic medications used. We will also measure the concentrations of markers of inflammation in the blood and lung as measures of VILI. Finally, throughout the study we will compare the adequacy of gas exchange with APRV compared to conventional MV.
Interventions
- DEVICE APRV
- DEVICE Conventional MV
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2008-07 |
| Est. Completion | 2008-10-15 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00750204
The ClinicalTrials.gov registry entry for NCT00750204 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 2 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which APRV is the first listed.
NCT00750204 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00750204 about?
NCT00750204 is a clinical study titled "Airway Pressure Release Ventilation in Acute Lung Injury". The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and requirements for sedative medications. We will also compare markers of infl...
What is the current status of trial NCT00750204?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2008-07. Estimated completion is 2008-10-15.
What interventions are being tested in trial NCT00750204?
The interventions under investigation include: APRV (DEVICE), Conventional MV (DEVICE).
Who is sponsoring clinical trial NCT00750204?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
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