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NCT00741013 · ClinicalTrials.gov registry record · Early Phase 1
Quantifying Airway Inflammation With Radiologic Tests
A Early Phase 1 study, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 22
- Enrollment target
NCT00741013: Completed Early Phase 1 study, sponsored by Washington University School of Medicine.
NCT00741013 is a Early Phase 1 study that has completed, run by Washington University School of Medicine. The registered enrollment target is 22 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (58% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00741013, a Early Phase 1 study, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 22 participants
- Enrollment target
Study Summary
In this randomized, double-blind, placebo controlled trial we used positron emission tomography to determine if lovastatin or recombinant human activated protein C exhibit anti-inflammatory effects in humans following intrabronchial installation of lipopolysaccharide (LPS or endotoxin).
Primary Outcome
Calculated Ki was used to measure the amount of lung inflammation before and after instillation of endotoxin to assess the effect of placebo, lovastatin, and rhAPC treatment
Interventions
- BIOLOGICAL Endotoxin
- DRUG placebo pill and placebo IV
- DRUG Lovastatin pill and placebo IV
- DRUG placebo pill and recombinant human activated protein C IV
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2007-03 |
| Est. Completion | 2008-03 |
| Phase | Early Phase 1 |
What the finished NCT00741013 record still lists
NCT00741013 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (58% lower).
The record links to 0 conditions, and to 4 interventions - of which Endotoxin is the first listed.
NCT00741013 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00741013 about?
NCT00741013 is a clinical study titled "Quantifying Airway Inflammation With Radiologic Tests". In this randomized, double-blind, placebo controlled trial we used positron emission tomography to determine if lovastatin or recombinant human activated protein C exhibit anti-inflammatory effects in humans following intrabronchial installation of lipopolysaccharide (LPS or endotoxin).
What is the current status of trial NCT00741013?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 22 participants. The study started on 2007-03. Estimated completion is 2008-03.
What interventions are being tested in trial NCT00741013?
The interventions under investigation include: Endotoxin (BIOLOGICAL), placebo pill and placebo IV (DRUG), Lovastatin pill and placebo IV (DRUG), placebo pill and recombinant human activated protein C IV (DRUG).
Who is sponsoring clinical trial NCT00741013?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00741013's enrollment target sits among peer trials
22 1104th of 2000 higher than 872 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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