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NCT00729690 · ClinicalTrials.gov registry record · Phase 3
Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement
A Phase 3 study, sponsored by Asokumar Buvanendran.
- Completed
- Registry status
- Phase 3
- Development phase
- 48
- Enrollment target
NCT00729690: Completed Phase 3 study, sponsored by Asokumar Buvanendran.
NCT00729690 is a Phase 3 study that has completed, run by Asokumar Buvanendran. The registered enrollment target is 48 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00729690, a Phase 3 study, has completed, sponsored by Asokumar Buvanendran.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 48 participants
- Enrollment target
Study Summary
This study involves research. Pregabalin is a Food and Drug Administration (FDA) medication approved in the United States for the treatment of nerve pain related to diabetes and post-herpetic neuralgia "shingles", and for seizures in adults. The purpose of this research is to study the effect of oral Pregabalin on spinal neurotransmitters in subjects undergoing Total Knee Replacement Surgery (TKA). TKA is associated with considerable postoperative pain which if unrelieved may result in prolonged hospital stay, inability to participate in rehabilitation programs, poor outcomes, and greater use of health-care resources. This study examines the effect of pregabalin administered for TKA on pain-related neurotransmitter concentrations.
Primary Outcome
Numerical Response scale NRS(0-10) Pain scores were collected every 4 hours after the initial dose and the Area Under the Curve (AUC) calculated. Calculated for the 1st 24 hours after initial dose (0-24hr). AUC measured in NRS pain score points per hour (NRS\*hr). Larger AUC values indicate higher levels of reported pain.
Interventions
- DRUG Placebo
- DRUG Pregabalin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2008-08 |
| Est. Completion | 2011-07 |
| Phase | Phase 3 |
What the finished NCT00729690 record still lists
NCT00729690 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00729690 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00729690 about?
NCT00729690 is a clinical study titled "Effect of Oral Pregabalin on Spinal Neurotransmitters in Patients Undergoing Knee Replacement". This study involves research. Pregabalin is a Food and Drug Administration (FDA) medication approved in the United States for the treatment of nerve pain related to diabetes and post-herpetic neuralgia "shingles", and for seizures in adults. The purpose of this research is to study the effect of ora...
What is the current status of trial NCT00729690?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 48 participants. The study started on 2008-08. Estimated completion is 2011-07.
What interventions are being tested in trial NCT00729690?
The interventions under investigation include: Placebo (DRUG), Pregabalin (DRUG).
Who is sponsoring clinical trial NCT00729690?
This trial is sponsored by Asokumar Buvanendran, which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00729690's enrollment target sits among peer trials
48 1862nd of 2000 higher than 134 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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