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NCT00725946 · ClinicalTrials.gov registry record · Early Phase 1
Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT
A Early Phase 1 study, sponsored by Stanford University.
- Terminated
- Registry status
- Early Phase 1
- Development phase
- 7
- Enrollment target
NCT00725946: Clinical Trial Early Phase 1 study, sponsored by Stanford University.
NCT00725946 is a Early Phase 1 study that was terminated before completion, run by Stanford University. The registered enrollment target is 7 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00725946, a Early Phase 1 study, was terminated before completion, sponsored by Stanford University.
- TERMINATED
- Registry status
- Early Phase 1
- Development phase
- 7 participants
- Enrollment target
Study Summary
This is a pilot imaging study for women whose tumors express NIS \[Na+I- symporter, sodium iodide symporter\]. Eligibility is limited to the presence of strong (3+) and/or plasma membrane staining in \> 20% of cells as determined by immunohistochemical methods. A total of 10 patients will be imaged with 124I PET/CT (serial scans over 24 hour period) to determine radioiodide uptake and distribution in tumor tissue. Thyroid iodide uptake and retention will be blocked beginning one week prior to 124I PET/CT scan with thyroid hormone (T3) and methimazole (impedes organification). Tumor, organ and whole body dosimetry will be calculated in each patient.
Primary Outcome
To evaluate radioiodide accumulation in women with immunohistochemically NIS (Na+/I- symporter)-positive breast cancers using 124I PET/CT.
Interventions
- DRUG Iodine-124
- RADIATION PET/CT with Iodine-124
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2008-02 |
| Est. Completion | 2012-12 |
| Phase | Early Phase 1 |
Why NCT00725946 stopped before completion
NCT00725946 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 2 interventions - of which Iodine-124 is the first listed.
NCT00725946 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00725946 about?
NCT00725946 is a clinical study titled "Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using 124I PET/CT". This is a pilot imaging study for women whose tumors express NIS \[Na+I- symporter, sodium iodide symporter\]. Eligibility is limited to the presence of strong (3+) and/or plasma membrane staining in \> 20% of cells as determined by immunohistochemical methods. A total of 10 patients will be imaged ...
What is the current status of trial NCT00725946?
This trial is currently terminated. It is a Early Phase 1 study. The enrollment target is 7 participants. The study started on 2008-02. Estimated completion is 2012-12.
What interventions are being tested in trial NCT00725946?
The interventions under investigation include: Iodine-124 (DRUG), PET/CT with Iodine-124 (RADIATION).
Who is sponsoring clinical trial NCT00725946?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00725946's enrollment target sits among peer trials
7 1825th of 2000 higher than 156 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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