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NCT00722280 · ClinicalTrials.gov registry record · NA
Human Upper Extremity (Hand and Forearm) Allotransplantation
A NA study, sponsored by University of Pittsburgh.
- Terminated
- Registry status
- NA
- Development phase
- 38
- Enrollment target
NCT00722280 is a NA study that was terminated before completion, run by University of Pittsburgh. The registered enrollment target is 38 participants.
The verdict
NCT00722280, a NA study, was terminated before completion, sponsored by University of Pittsburgh.
- TERMINATED
- Registry status
- NA
- Development phase
- 38 participants
- Enrollment target
Study Summary
Overall Goal To establish hand transplantation as a safe and effective reconstructive strategy for the treatment of upper extremity amputations. Specific Aim To reduce the risk of rejection and enable allograft survival while minimizing the requirement for long term high dose immunosuppression. For this purpose, we propose to utilize the "Pittsburgh Protocol", which is an immunomodulatory strategy that has been implemented in solid organ transplants at UPMC. Early results in living related liver and kidney patients have confirmed that this protocol provides the means to allow graft survival with minimization of maintenance immunosuppression and even allows weaning of some patients from long-term immunosuppression.We hypothesize that a similar protocol can enable graft survival in highly immunogenic composite tissue allografts like hand transplants while reducing the number,dosing and/or frequency of immunosuppressive drugs associated with serious adverse effects.
Interventions
- PROCEDURE Hand Transplantation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 38 participants |
| Start Date | 2008-12 |
| Est. Completion | 2017-10 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00722280
The ClinicalTrials.gov registry entry for NCT00722280 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 38 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Hand Transplantation is the first listed.
NCT00722280 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00722280 about?
NCT00722280 is a clinical study titled "Human Upper Extremity (Hand and Forearm) Allotransplantation". Overall Goal To establish hand transplantation as a safe and effective reconstructive strategy for the treatment of upper extremity amputations. Specific Aim To reduce the risk of rejection and enable allograft survival while minimizing the requirement for long term high dose immunosuppression. ...
What is the current status of trial NCT00722280?
This trial is currently terminated. It is a NA study. The enrollment target is 38 participants. The study started on 2008-12. Estimated completion is 2017-10.
What interventions are being tested in trial NCT00722280?
The interventions under investigation include: Hand Transplantation (PROCEDURE).
Who is sponsoring clinical trial NCT00722280?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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