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COMPLETED Phase 1

Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma

NCT00720174 · View on ClinicalTrials.gov ↗

Study Summary

This phase I trial is studying the side effects and best dose of cixutumumab given together with doxorubicin hydrochloride and to see how well they work in treating patients with unresectable, locally advanced, or metastatic soft tissue sarcoma. Monoclonal antibodies, such as cixutumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibody cixutumumab together with doxorubicin hydrochloride may kill more tumor cells.

Interventions

  • OTHER Laboratory Biomarker Analysis
  • DRUG Doxorubicin Hydrochloride
  • BIOLOGICAL Cixutumumab

Study Locations (13)

Illinois

  • University of Chicago Comprehensive Cancer Center — Chicago
  • Decatur Memorial Hospital — Decatur
  • NorthShore University HealthSystem-Evanston Hospital — Evanston
  • Ingalls Memorial Hospital — Harvey
  • Joliet Oncology-Hematology Associates Limited — Joliet
  • Loyola University Medical Center — Maywood
  • Illinois CancerCare-Peoria — Peoria
  • Central Illinois Hematology Oncology Center — Springfield

Indiana

  • Fort Wayne Medical Oncology and Hematology Inc-Parkview — Fort Wayne

Maryland

  • University of Maryland/Greenebaum Cancer Center — Baltimore

Michigan

  • University of Michigan Comprehensive Cancer Center — Ann Arbor

Missouri

  • Mercy Hospital Saint Louis — St Louis

Wisconsin

  • Froedtert and the Medical College of Wisconsin — Milwaukee

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2008-06
Phase Phase 1

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00720174

The ClinicalTrials.gov registry entry for NCT00720174 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Adult Angiosarcoma appearing as the primary indexed condition, and to 3 interventions — of which Laboratory Biomarker Analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00720174 reports 13 study locations spanning 6 distinct geographic areas — top geographies include Illinois, Indiana, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00720174 about?

NCT00720174 is a clinical study titled "Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma". This phase I trial is studying the side effects and best dose of cixutumumab given together with doxorubicin hydrochloride and to see how well they work in treating patients with unresectable, locally advanced, or metastatic soft tissue sarcoma. Monoclonal antibodies, such as cixutumumab, can block ...

What is the current status of trial NCT00720174?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2008-06.

What conditions does trial NCT00720174 study?

This clinical trial studies the following conditions: Adult Angiosarcoma, Adult Epithelioid Sarcoma, Adult Leiomyosarcoma, Adult Liposarcoma, Adult Desmoplastic Small Round Cell Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00720174?

The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Doxorubicin Hydrochloride (DRUG), Cixutumumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00720174?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00720174 being conducted?

This trial has 13 study locations across Illinois, Indiana, Maryland, Michigan, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial