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COMPLETED Phase 2

Study of AMG 479 as Second Line Therapy in Patients With Recurrent Platinum-sensitive Ovarian Cancer

NCT00719212 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to obtain an estimate of the objective response rate (ORR) of AMG 479 in patients with recurrent platinum-sensitive ovarian epithelial (including fallopian tube and primary peritoneal) carcinoma failing frontline chemotherapy.

Conditions Studied

Interventions

  • BIOLOGICAL AMG 479

Study Locations (20)

California

  • Comprehensive Blood and Cancer Center — Bakersfield
  • St Jude Heritage Healthcare — Fullerton
  • Wilshire Oncology Medical Group Inc — La Verne
  • LAC/USC Medical Center — Los Angeles
  • University of Southern California/ Norris Comprehensive Cancer Center — Los Angeles
  • Cedars Sinai Medical Center — Los Angeles
  • UCLA — Los Angeles
  • North Valley Hematology/ Oncology Medical Group — Northridge
  • Ventura County Hematology Oncology Specialists — Oxnard
  • Central Hematology Oncology Medical Group Inc. — Pasadena

Other

  • Tom Baker Centre — Calgary
  • Juravinski Cancer Center — Hamilton
  • CHUM Hôpital Notre Dama — Montreal
  • Jewish General Hospital — Montreal

Colorado

  • University of Colorado — Aurora

Illinois

  • University of Chicago — Chicago

Kansas

  • Cancer Center of Kansas — Wichita

Michigan

  • St Joseph Mercy Health System — Ann Arbor

Minnesota

  • Mayo Clinic — Rochester

Nevada

  • Comprehensive Cancer Centre of Nevada — Henderson

Trial Details

FieldValue
Enrollment Target 61 participants
Start Date 2009-01
Est. Completion 2013-05
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00719212

The ClinicalTrials.gov registry entry for NCT00719212 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 61 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Translational Research in Oncology, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ovarian Neoplasms appearing as the primary indexed condition, and to 1 intervention — of which AMG 479 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00719212 reports 20 study locations spanning 8 distinct geographic areas — top geographies include California, Other, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00719212 about?

NCT00719212 is a clinical study titled "Study of AMG 479 as Second Line Therapy in Patients With Recurrent Platinum-sensitive Ovarian Cancer". The purpose of this study is to obtain an estimate of the objective response rate (ORR) of AMG 479 in patients with recurrent platinum-sensitive ovarian epithelial (including fallopian tube and primary peritoneal) carcinoma failing frontline chemotherapy.

What is the current status of trial NCT00719212?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 61 participants. The study started on 2009-01. Estimated completion is 2013-05.

What conditions does trial NCT00719212 study?

This clinical trial studies the following conditions: Ovarian Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00719212?

The interventions under investigation include: AMG 479 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00719212?

This trial is sponsored by Translational Research in Oncology, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00719212 being conducted?

This trial has 20 study locations across California, Colorado, Illinois, Kansas, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial