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NCT00689026 · ClinicalTrials.gov registry record · NA
Efficacy of Lubiprostone in Combination With Standard PEG Preparation
A NA study, sponsored by Augusta University.
- Terminated
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT00689026: Clinical Trial NA study, sponsored by Augusta University.
NCT00689026 is a NA study that was terminated before completion, run by Augusta University. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00689026, a NA study, was terminated before completion, sponsored by Augusta University.
- TERMINATED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
A large population-based study has shown diabetes to be an independent risk factor for colon cancer compared to the general population. Thus, the completion of an adequately prepped colonoscopy is requisite in providing diabetics with adequate colon cancer screening. Recent data has shown that diabetic patients have poorer response to bowel cleansing compared to non-diabetics (with a standard PEG prep, only 62% of diabetic patients had their colonoscopy preps rated as good or better vs. 97% of normal patients, p\<0.001). This may be due to the fact that a majority of diabetic patients report constipation as a common gastrointestinal complaint. We postulate that lubiprostone (Amitiza), in combination with PEG, will have additional efficacy over standard PEG preparation, and provide optimal safe and effective colonic cleansing for diabetics.
Primary Outcome
The quality of colonoscopy preparations as rated by blinded colonoscopists on a 5-point Likert Scale where 1=excellent, 2=good, 3=fair, 4=poor, 5=inadequate. It was expected that at least 100 patients would complete the trial.
Interventions
- DRUG Lubiprostone
- OTHER Polyethylene glycol with electrolytes
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2008-05 |
| Est. Completion | 2010-03 |
| Phase | NA |
Why NCT00689026 stopped before completion
NCT00689026 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Lubiprostone is the first listed.
NCT00689026 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00689026 about?
NCT00689026 is a clinical study titled "Efficacy of Lubiprostone in Combination With Standard PEG Preparation". A large population-based study has shown diabetes to be an independent risk factor for colon cancer compared to the general population. Thus, the completion of an adequately prepped colonoscopy is requisite in providing diabetics with adequate colon cancer screening. Recent data has shown that diab...
What is the current status of trial NCT00689026?
This trial is currently terminated. It is a NA study. The enrollment target is 60 participants. The study started on 2008-05. Estimated completion is 2010-03.
What interventions are being tested in trial NCT00689026?
The interventions under investigation include: Lubiprostone (DRUG), Polyethylene glycol with electrolytes (OTHER).
Who is sponsoring clinical trial NCT00689026?
This trial is sponsored by Augusta University, which has 106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00689026's enrollment target sits among peer trials
60 1164th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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